The role of the MIND diet in Alzheimer's disease patients: A case-control study on malnutrition and depression
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View abstract on PubMed
Summary
This summary is machine-generated.Adhering to the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) diet is linked to better nutrition and mental health in Alzheimer's disease (AD) patients. Higher MIND diet adherence correlates with reduced malnutrition and depression symptoms in individuals with AD.
Area Of Science
- Neuroscience
- Nutritional Science
- Gerontology
Background
- Alzheimer's disease (AD) is a progressive neurodegenerative disorder.
- Malnutrition and depression are common comorbidities in AD patients.
- Dietary interventions are being explored to manage AD symptoms.
Purpose Of The Study
- To investigate the relationship between depression, malnutrition, and adherence to the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) diet in Alzheimer's disease patients.
- To assess the impact of the MIND diet on nutritional status and mental health in AD.
- To determine the risk factors associated with AD development and progression.
Main Methods
- A case-control study involving 30 Alzheimer's disease (AD) patients and 30 healthy controls.
- Data collection included sociodemographic information, anthropometric measurements, biochemical parameters, nutritional assessments (FFQ, MNA-SF, GNRI, MIND diet scores), and mental health evaluations (BDI, BAI).
- Statistical analyses included independent t-tests, correlation analyses, logistic regression, and ROC analysis.
Main Results
- Alzheimer's disease patients exhibited significantly higher depression (BDI) and anxiety (BAI) scores compared to controls.
- MIND diet adherence was significantly lower in the AD group.
- Higher MIND diet adherence was associated with lower malnutrition and depression scores in AD patients.
- High malnutrition status increased AD risk (OR=2.034), while high MIND diet score increased the chance of being healthy (OR=2.879).
- Depression score showed high diagnostic accuracy for AD (AUC=0.946).
Conclusions
- Adherence to the MIND diet may positively influence nutritional status and psychological well-being in individuals with Alzheimer's disease.
- Integrating nutrition-focused strategies, particularly the MIND diet, into dementia care is recommended.
- Dietary interventions show promise in supporting cognitive health and managing AD comorbidities.
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