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Updated: Jan 18, 2026

Identifying Inhibitors of the HBx-DDB1 Interaction Using a Split Luciferase Assay System
Published on: December 21, 2019
A small molecule with larger-than-expected effects on hepatitis B virus
Ashwin Balagopal1, Andrea L Cox1
1The Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Abstract:
Chronic hepatitis B virus (HBV) affects ∼250 million people worldwide. Functional cure is difficult to achieve with existing medications. In this issue, Fernandes et al. developed a double-humanized chronic HBV murine model to test the capsid assembly modulator GLP-26. GLP-26 reduced blood HBV DNA and surface antigen and induced immunomodulation.
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