Impact of universal nirsevimab prophylaxis in infants on hospital and primary care outcomes across two respiratory syncytial virus seasons in Galicia, Spain (NIRSE-GAL): a population-based prospective observational study
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View abstract on PubMed
Summary
This summary is machine-generated.Universal infant nirsevimab prophylaxis significantly reduced respiratory syncytial virus (RSV) hospitalizations and outpatient illness in its first season. The protection extended into the second season for RSV-related hospitalizations, showing sustained benefits without adverse effects.
Area Of Science
- Pediatric Infectious Diseases
- Immunization Programs
- Public Health Surveillance
Background
- Emerging real-world data on nirsevimab's impact beyond the first season in universal immunization programs.
- Need to assess the medium-term effectiveness of universal infant prophylaxis against respiratory syncytial virus (RSV).
Purpose Of The Study
- To evaluate the medium-term impact of universal infant nirsevimab prophylaxis on RSV-related morbidity.
- Assess effectiveness across inpatient and outpatient settings over two consecutive RSV seasons.
Main Methods
- Population-based, prospective longitudinal study (NIRSE-GAL) in Galicia, Spain.
- Inclusion of infants eligible for nirsevimab during the 2023-24 RSV campaign.
- Comparison with historical non-pandemic seasons (2017-18 to 2022-23) using Poisson regression.
Main Results
- 94.4% coverage with nirsevimab achieved in eligible infants.
- Significant reductions observed in RSV-related LRTI hospitalizations (85.9% first season, 55.3% second season).
- Decreases in acute bronchitis/bronchiolitis admissions (59.0% first season, 58.7% up to 18 months) and outpatient visits.
Conclusions
- Universal infant nirsevimab prophylaxis markedly reduced RSV hospitalizations and outpatient morbidity.
- Sustained reductions in RSV-related LRTI hospitalizations into the second season were observed.
- No evidence of an adverse shift in RSV morbidity, supporting its value for immunization policies.
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