Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Open Angle Glaucoma: Treatment01:27

Open Angle Glaucoma: Treatment

963
In open-angle glaucoma, the iridocorneal angle remains open, but the trabecular meshwork becomes stiff, slowing down the outflow of aqueous humor. This causes a buildup of aqueous humor in the anterior chamber, leading to a sudden increase in intraocular pressure. The treatment for open-angle glaucoma focuses on reducing the elevated intraocular pressure by either decreasing the secretion of aqueous humor or increasing its outflow.
Drugs such as carbonic anhydrase inhibitors, α2- and...
963
Angle Closure Glaucoma: Treatment01:28

Angle Closure Glaucoma: Treatment

1.2K
Angle-closure glaucoma, or closed-angle glaucoma, is an eye condition where the iris bulges out and blocks the iridocorneal angle, resulting in a buildup of aqueous humor and increased intraocular pressure. Immediate medical attention is necessary due to the sudden onset of symptoms. The treatment for angle-closure glaucoma includes short-term and long-term approaches. Short-term treatment involves using eye drops like pilocarpine to lower intraocular pressure by increasing aqueous humor...
1.2K
Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

715
Drug delivery methods like oral inhalation, nasal sprays, transdermal patches, eye drops, intravitreal injection,  and rectal administration provide localized effects with reduced toxicity.
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
715
Glaucoma: Overview01:25

Glaucoma: Overview

1.3K
Glaucoma is an eye condition characterized by increased intraocular pressure that damages the retina and optic nerve, leading to irreversible blindness if left untreated. The human eye has various components, including the cornea, iris, pupil, lens, and optic nerve. Aqueous humor is secreted by the epithelium of the ciliary body in the posterior chamber and flows through the trabecular meshwork and canal of Schlemm, maintaining normal intraocular pressure. The trabecular meshwork and the canal...
1.3K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Real-world effectiveness of a binocular, dual-mechanism therapy in severe amblyopia: analysis from the PUPiL Registry.

Journal of AAPOS : the official publication of the American Association for Pediatric Ophthalmology and Strabismus·2026
Same author

Mesoscale developmental rivalry in the human extrastriate visual cortex.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same author

Genome-Wide Association Study for Glucocorticoid-Induced Ocular Hypertension.

Ophthalmology science·2026
Same author

Association between Glucagon-like Peptide-1 Receptor Agonist Use and Nonarteritic Anterior Ischemic Optic Neuropathy with Optic Disc Drusen.

Ophthalmology·2026
Same author

Circuit dynamics of binocular conflict in mouse primary visual cortex.

Frontiers in systems neuroscience·2026
Same author

Equivalent effectiveness of a prescription binocular treatment for amblyopia in real-world practice.

Journal of managed care & specialty pharmacy·2026

Related Experiment Video

Updated: Jan 18, 2026

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

1.6K

Substance Use Disorder Interventions and Ophthalmic Outcomes for Injection Drug Use-Associated Endogenous

Jared T Sokol1, David J Krasinski2, George N Papaliodis3

  • 1Department of Ophthalmology, Sue Anschutz-Rodgers Eye Center, University of Colorado School of Medicine, Aurora, Colorado.

Ophthalmology. Retina
|January 15, 2026
PubMed
Summary

Ophthalmologists treating injection drug use-associated endogenous endophthalmitis (IDU-EE) can improve patient outcomes through addiction consult services. Fentanyl use is linked to worse visual prognosis in IDU-EE patients.

Keywords:
AddictionEndogenous endophthalmitisFentanylIntravenous drug useOpioid use disorder

More Related Videos

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

12.7K
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

902

Related Experiment Videos

Last Updated: Jan 18, 2026

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology
06:19

Author Spotlight: A Novel Protocol for Intracameral Injections to Enhance Precision in Rodent Ophthalmology

Published on: May 31, 2024

1.6K
Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis
07:24

Intravitreal Injection and Quantitation of Infection Parameters in a Mouse Model of Bacterial Endophthalmitis

Published on: February 6, 2021

12.7K
Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats
06:30

Ocular Therapeutic Delivery and Advanced Tissue Retrieval in Adult Rats

Published on: May 23, 2025

902

Area of Science:

  • Ophthalmology
  • Infectious Diseases
  • Addiction Medicine

Background:

  • Injection drug use-associated endogenous endophthalmitis (IDU-EE) is a serious complication linked to the opioid epidemic.
  • Ophthalmologists play a crucial role in managing IDU-EE and can integrate care with substance use disorder (SUD) treatment.

Purpose of the Study:

  • To examine factors influencing SUD care and ophthalmic outcomes in IDU-EE patients.
  • To identify opportunities for intervention in the management of IDU-EE.
  • To analyze historical trends in IDU-EE and associated SUD care.

Main Methods:

  • Retrospective cohort study of patients diagnosed with IDU-EE from 2015-2021.
  • Analysis of clinical features, SUD treatment, and ophthalmic outcomes.
  • Evaluation of addiction medicine outcomes (drug type, addiction consult service (ACS) consultation, medication for opioid use disorder (MOUD) initiation) and ophthalmic outcomes (visual acuity (VA), interventions, sequelae, organism identification).

Main Results:

  • Heroin, cocaine, and fentanyl were the primary injected drugs. Initial treatments included tap and inject (TAI) and pars plana vitrectomy (PPV).
  • PPV was more likely to yield positive cultures than TAI. Median VA improved significantly, but retinal detachment occurred in 23.1% of eyes.
  • Fentanyl use correlated with significantly worse final visual acuity. Addiction consult services were associated with MOUD initiation, with over half of eligible patients accepting treatment.

Conclusions:

  • Addiction consult services are vital for managing IDU-EE patients and improving care.
  • The incidence and visual outcomes of IDU-EE may be worsening, particularly with increased fentanyl use.
  • Early vitrectomy may improve pathogen identification in IDU-EE.