[Extracellular matrix materials and tissue regeneration and repair]

Area of Science:

• Biomaterials Science
• Regenerative Medicine
• Tissue Engineering

Background:

• The extracellular matrix (ECM) is crucial for cell behavior, tissue repair, and regeneration.
• ECM's structural and bioactive properties support cell growth and orchestrate healing via signaling pathways.

Purpose of the Study:

• To systematically review ECM preparation strategies for tissue regeneration.
• To highlight advances in component preservation, structural biomimicry, and functional optimization of ECM materials.
• To explore the potential of emerging technologies in ECM engineering for regenerative medicine.

Main Methods:

• Literature review synthesizing preparation strategies for natural and engineered ECM.
• Analysis of ECM-mediated tissue regeneration mechanisms.
• Examination of advanced technologies (AI, flexible electronics, organoids) in ECM engineering.

Main Results:

• ECM preparation strategies are advancing with focus on component preservation, structural biomimicry, and functional optimization.
• Emerging technologies show promise for enhancing ECM-based regenerative medicine platforms.
• Challenges in standardization and safety require critical analysis for clinical translation.

Conclusions:

• Next-generation ECM-based regenerative medicine platforms can be constructed based on synthesized strategies and technological integration.
• Optimizing ECM material preparation is vital for effective tissue regeneration.
• Addressing clinical translation challenges is essential for advancing ECM therapies.