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Updated: Jan 18, 2026

Effects of Allogeneic Platelet-Rich Plasma PRP on the Healing Process of Sectioned Achilles Tendons of Rats: A Methodological Description
Published on: March 19, 2018
[Research progress on extracellular vesicles derived from platelet-rich plasma in tissue repair and regeneration]
Jiaxuan Han1,2, Biao Cheng1,2
1The First Clinical Medical School of Guangdong Pharmaceutical University, Guangzhou Guangdong, 510080, P. R. China.
Objective:
To delineate the mechanistic role of platelet-rich plasma (PRP)-derived extracellular vesicles (EVs) in tissue repair and regeneration, and evaluate their clinical translation potential.
Methods:
A systematic evidence synthesis was conducted through critical analysis of contemporary domestic and international literature, focusing on PRP-EVs' biophysical properties, signal transduction networks, and multi-tissue regenerative efficacy.
Results:
PRP-EVs coordinate hemostasis, anti-inflammatory modulation, angiogenesis, and tissue plasticity through mediation of cellular proliferation, migration, and differentiation. Their low immunogenicity and biostability constitute a novel cell-free therapeutic paradigm.
Conclusion:
PRP-EVs exhibit substantial translational merit in regenerative medicine, yet persistent impediments in standardized isolation protocols, longitudinal biosafety verification, and clinical translation frameworks necessitate resolution.
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