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Development and Assessment of Intracellular Infection Models for Staphylococcus aureus
Published on: January 17, 2025
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Prostatic abscesses as a cause of persistent Staphylococcus aureus bacteremia
Valeria Ferrando-Mérida1, Marina Machado2, Carmen Cuenca3
1Clinical Microbiology and Infectious Disease Department, Hospital General Universitario Gregorio Marañón, Madrid, Spain; Instituto de Investigación Sanitaria Gregorio Marañón (IiSGM), Madrid, Spain.
Enfermedades Infecciosas Y Microbiologia Clinica (English Ed.)
|January 15, 2026
Summary
Prostatic abscesses can cause persistent Staphylococcus aureus bacteremia (SAB). Early diagnosis and treatment, including surgical drainage and antibiotics, are key to resolving SAB and improving patient outcomes.
Area of Science:
- Infectious Diseases
- Urology
- Internal Medicine
Background:
- Persistent Staphylococcus aureus bacteremia (SAB) carries a high mortality risk.
- Identifying the infectious source is crucial for managing SAB.
- Prostatic abscesses are an underrecognized cause of persistent SAB, particularly in men with urinary issues.
Purpose of the Study:
- To highlight prostatic abscesses as a potential source of persistent Staphylococcus aureus bacteremia (SAB).
- To emphasize the importance of considering prostatic abscesses in the differential diagnosis of unexplained persistent SAB.
Main Methods:
- Presentation of two cases with persistent methicillin-susceptible Staphylococcus aureus (MSSA) bacteremia.
- Diagnosis of prostatic abscesses as the occult source after initial evaluations failed to identify a focus.
- Treatment involved transurethral drainage of abscesses combined with extended antibiotic therapy.
Main Results:
- Successful resolution of bacteremia in both patients following combined treatment.
- Favorable clinical outcomes achieved through source control and appropriate antimicrobial management.
- Demonstrates the efficacy of surgical drainage and antibiotics for prostatic abscess-related SAB.
Conclusions:
- Prostatic abscesses must be considered in patients with persistent SAB, especially those with urinary symptoms or risk factors.
- Prompt diagnosis and source control, including surgical drainage, are essential for successful treatment.
- Integrated management of antibiotics and abscess drainage leads to clinical cure in persistent SAB due to prostatic abscess.
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