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Related Experiment Video

Updated: Jan 18, 2026

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Prolonged zinc use for dysgeusia causing copper deficiency.

Min Ji Kim1, Michael Jay Tang1, Eduardo Bruera1

  • 1Department of Palliative Care, Rehabilitation, and Integrative Medicine, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.

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PubMed
Summary

Prolonged zinc supplementation can cause copper deficiency, leading to fatigue, anemia, and neurological issues. Prompt diagnosis and treatment of hypocupremia are crucial to prevent permanent damage.

Keywords:
Zinccopper deficiencydysgeusiahypocupremiazinc supplementation

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Area of Science:

  • Nutritional Science
  • Hematology
  • Neurology

Background:

  • Zinc is vital for taste perception and used for dysgeusia in cancer patients.
  • Overconsumption of zinc can lead to copper deficiency, an under-recognized condition.
  • Copper deficiency symptoms include fatigue, nausea, anemia, and myelopathy.

Purpose of the Study:

  • To highlight the risk of copper deficiency due to prolonged zinc supplementation.
  • To present a case of hypocupremia in a patient with multiple myeloma.

Main Methods:

  • A case study of a patient in his 70s with multiple myeloma and gastroparesis.
  • Patient presented with symptoms of fatigue, anemia, and neurological deficits after 2 years of zinc supplementation.
  • Diagnosis of hypocupremia confirmed, followed by inpatient treatment with IV cupric chloride.

Main Results:

  • The patient experienced gradual symptom improvement over 5-6 weeks following IV cupric chloride treatment.
  • Hypocupremia was identified as the cause of the patient's symptoms.
  • Neurological and hematological deficits improved with copper repletion.

Conclusions:

  • Clinicians must screen for copper deficiency in patients on zinc supplements.
  • Avoid prolonged zinc courses or overprescribing to prevent hypocupremia.
  • Prompt diagnosis and treatment of hypocupremia are essential to avoid irreversible neurological damage.