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Updated: Jan 18, 2026

Synthesis of a Thiol Building Block for the Crystallization of a Semiconducting Gyroidal Metal-sulfur Framework
Published on: April 9, 2018
Electrochemical desulfurative borylation of thiols, disulfides, thioethers and thioacetals
Julius Kuzmin1, Cristiana Margarita1,2, Johannes Winter1
1Department of Chemistry, KTH Royal Institute of Technology, Stockholm, Sweden.
Abstract:
Low-valent sulfur-containing compounds are abundant among natural and synthetic products but remain underutilized as starting materials in desulfurative transformations. Herein, we present thiols, disulfides, thioethers, and thioacetals as precursors in a direct desulfurative electrochemical process for the formation of alkylboronic esters, including late-stage functionalization of pharmaceutically relevant scaffolds and natural products. The electrochemical protocol is simple, user-friendly and scalable, successfully producing gram quantities of borylated product.
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