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Captopril-induced Cough: Does it Matter in Children? A Retrospective Cohort Study

Michael Coffey1, Brian McCrossan2, Rachel Moore1

  • 1Paediatrics, Royal Belfast Hospital for Sick Children, Belfast, UK.

Current Pediatric Reviews
|January 16, 2026
PubMed

Insights

Cough from ACE inhibitors (ACE-I) like captopril is less common in children than adults, affecting 15% of patients. This side effect is generally well-tolerated and rarely requires medication changes.

Area of Science:

  • Pediatric Cardiology
  • Pharmacology
  • Clinical Research

Background:

  • Angiotensin-converting enzyme inhibitors (ACE-I) are frequently prescribed for pediatric cardiovascular conditions.
  • Captopril-induced cough is anecdotally reported less often in children compared to adults.

Purpose of the Study:

  • To investigate the prevalence and impact of ACE-I-related cough in pediatric cardiology patients.
  • To compare the incidence of captopril-induced cough in children versus adults.

Main Methods:

  • A retrospective cohort study involving 100 pediatric cardiology patients on regular ACE-I.
  • Data collection via telephone interviews and questionnaires assessing cough symptoms.

Main Results:

  • 15% of pediatric patients reported captopril-related cough symptoms.
  • Only 1% of patients required a change in medication due to cough.
  • ACE-I-related cough in children is generally well-tolerated.

Conclusions:

  • Captopril-related cough appears less significant in children than in adults, though potentially more prevalent than previously assumed.
  • The lower incidence may relate to differences in ACE expression between pediatric and adult lungs.
  • ACE-I-associated cough rarely necessitates changes in pediatric patient management.
Abstract

Keywords:
Coughcaptoprilcaptopril coughcardiologypediatrics.pharmacology

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