Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Catalysis02:50

Catalysis

30.1K
The presence of a catalyst affects the rate of a chemical reaction. A catalyst is a substance that can increase the reaction rate without being consumed during the process. A basic comprehension of a catalysts’ role during chemical reactions can be understood from the concept of reaction mechanisms and energy diagrams.
30.1K
Cycloaddition Reactions: MO Requirements for Photochemical Activation01:12

Cycloaddition Reactions: MO Requirements for Photochemical Activation

2.6K
Some cycloaddition reactions are activated by heat, while others are initiated by light. For example, a [2 + 2] cycloaddition between two ethylene molecules occurs only in the presence of light. It is photochemically allowed but thermally forbidden.
2.6K
Reduction of Alkenes: Asymmetric Catalytic Hydrogenation02:17

Reduction of Alkenes: Asymmetric Catalytic Hydrogenation

3.8K
Catalytic hydrogenation of alkenes is a transition-metal catalyzed reduction of the double bond using molecular hydrogen to give alkanes. The mode of hydrogen addition follows syn stereochemistry.
The metal catalyst used can be either heterogeneous or homogeneous. When hydrogenation of an alkene generates a chiral center, a pair of enantiomeric products is expected to form. However, an enantiomeric excess of one of the products can be facilitated using an enantioselective reaction or an...
3.8K
Photochemical Electrocyclic Reactions: Stereochemistry01:26

Photochemical Electrocyclic Reactions: Stereochemistry

2.2K
The absorption of UV–visible light by conjugated systems causes the promotion of an electron from the ground state to the excited state. Consequently, photochemical electrocyclic reactions proceed via the excited-state HOMO rather than the ground-state HOMO. Since the ground- and excited-state HOMOs have different symmetries, the stereochemical outcome of electrocyclic reactions depends on the mode of activation; i.e., thermal or photochemical.
Selection Rules: Photochemical Activation
2.2K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Photocatalyzed oxidative cleavage of alkenes using CO<sub>2</sub> as an oxygen donor.

Science (New York, N.Y.)·2026
Same author

Selective Para-Functionalization of Aromatic C(sp<sup>2</sup>)─H Bonds via Atomically Dispersed Photocatalysis.

Angewandte Chemie (International ed. in English)·2026
Same author

Turning Sunlight and Seawater Into Energy: Photocatalytic Hydrogen Peroxide as a Green Fuel Carrier.

Advanced materials (Deerfield Beach, Fla.)·2026
Same author

Innovative approaches to the synthesis of five-membered heteroaromatics with emerging synthetic methodologies.

Chemical Society reviews·2026
Same author

EDA Complex-Driven Desaturation of Heterocyclic Carbonyl Compounds Enabled by HFIP.

Angewandte Chemie (International ed. in English)·2025
Same author

Seawater to Sustainable Fuel: Sunlight-Driven Green Hydrogen Generation with an Atomically Dispersed Photocatalyst.

Journal of the American Chemical Society·2025

Related Experiment Video

Updated: Jan 18, 2026

Synthesis and Performance Evaluations of ZnCoS/ZnCdS with Twin Crystal Structure for Multifunctional Redox Photocatalysis in Energy Applications
09:22

Synthesis and Performance Evaluations of ZnCoS/ZnCdS with Twin Crystal Structure for Multifunctional Redox Photocatalysis in Energy Applications

Published on: July 25, 2025

681

Heterogeneous Photocatalysis for Late-Stage Functionalization: A Sustainable Frontier for Complex Molecule Synthesis.

Prakash Kumar Sahoo1, Shoubhik Das2

  • 1Department of Chemistry, National Institute of Technology, Raipur, India.

Chemsuschem
|January 16, 2026
PubMed
Summary
This summary is machine-generated.

Heterogeneous photocatalysis is emerging as a sustainable alternative to homogeneous methods for late-stage functionalization (LSF). Advances in materials engineering enhance catalyst performance for complex molecule synthesis.

Keywords:
covalent organic framework (COF)late stage functionalization (LSF)metal–organic frameworks (MOFs)quantum dotssustainability

More Related Videos

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

14.3K
Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

7.7K

Related Experiment Videos

Last Updated: Jan 18, 2026

Synthesis and Performance Evaluations of ZnCoS/ZnCdS with Twin Crystal Structure for Multifunctional Redox Photocatalysis in Energy Applications
09:22

Synthesis and Performance Evaluations of ZnCoS/ZnCdS with Twin Crystal Structure for Multifunctional Redox Photocatalysis in Energy Applications

Published on: July 25, 2025

681
Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS
06:34

Synthesis of Antiviral Tetrahydrocarbazole Derivatives by Photochemical and Acid-catalyzed C-H Functionalization via Intermediate Peroxides CHIPS

Published on: June 20, 2014

14.3K
Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs
08:25

Development of Heterogeneous Enantioselective Catalysts using Chiral Metal-Organic Frameworks MOFs

Published on: January 17, 2020

7.7K

Area of Science:

  • Organic Chemistry
  • Materials Science
  • Sustainable Chemistry

Background:

  • Late-stage functionalization (LSF) is crucial for drug discovery and chemical biology.
  • Homogeneous photocatalysis traditionally dominates LSF, but faces sustainability challenges.
  • Heterogeneous photocatalysis offers potential for enhanced reactivity, selectivity, and recyclability.

Purpose of the Study:

  • To review the evolution of heterogeneous photocatalytic systems for selective LSF.
  • To connect materials chemistry advancements with photoredox catalysis.
  • To highlight the potential of heterogeneous photocatalysts in complex molecule synthesis.

Main Methods:

  • Surveying recent literature on heterogeneous photocatalytic systems.
  • Analyzing advancements in materials engineering for catalysts.
  • Connecting materials chemistry with photoredox catalysis principles.

Main Results:

  • Nanoscale re-engineering of classical photocatalysts (metal oxides, carbon nitrides) improves LSF.
  • Emerging materials like covalent organic frameworks (COFs) and metal-organic frameworks (MOFs) show promise.
  • Heterogeneous systems demonstrate enhanced reactivity, selectivity, and recyclability.

Conclusions:

  • Heterogeneous photocatalysis is a rapidly evolving field for LSF.
  • Materials innovation is key to unlocking the potential of these systems.
  • Heterogeneous photocatalysts offer scalable and sustainable solutions for synthesizing complex molecules.