Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Tandem Mass Spectrometry

Tandem Mass Spectrometry

Tandem mass spectrometry is a technique that uses multiple mass analyzers in series to obtain a higher selectivity and reduce chemical noise during analyte detection. Instruments with multiple analyzers separated by an interaction cell enable secondary fragmentation and selected study of the fragment ions.Secondary fragmentations occur in the interaction cell and can be induced by various factors. Fragmentation induced by collision with inert gases, such as N2, Ar, He, etc., is called...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Surface Electrochemistry of Au(111) in Acetonitrile Based Electrolytes: Formation of a Solvent Related Adsorbed Layer.

The journal of physical chemistry letters·2026

Same author

Mechanistic Insights Into Nitric Oxide Capture and Release in a Radical-Scavenging Zinc Ascorbate Metal-Organic Framework.

Small science·2026

Same author

Contemporary Techniques and Prospects in Pharmaceutical Tablet Surface Analysis.

ACS measurement science au·2026

Same author

Flavourings, nicotine content, and elemental composition as indicators of regulatory compliance in nicotine pouches and heated tobacco products.

The Analyst·2026

Same author

Platinum surface oxides govern the cathodic overpotential of the oxygen reduction reaction.

EES catalysis·2026

Same author

An anticoagulant activity and protein interaction study of chondroitin sulfate-coated magnetic nanocomposites.

International journal of biological macromolecules·2026

Search research articles

Related Experiment Video

Updated: Jan 18, 2026

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions

Published on: June 16, 2014

Combining ToF-SIMS and Multivariate Analysis to Resolve Active Sites on Ni-Based HER Catalysts.

Matjaž Finšgar¹, Katja Andrina Varda¹, Dzevad K Kozlica^1,2,3

¹Faculty of Chemistry and Chemical Engineering, University of Maribor, Maribor, 2000, Slovenia.

Angewandte Chemie (International Ed. in English)

|January 16, 2026

Summary

This summary is machine-generated.

Identifying active sites in catalysis is challenging. This study combines ToF-SIMS with statistical analysis to map nanoscale catalytic sites, revealing a marker for hydrogen evolution reaction activity on nickel electrodes.

Keywords:

HER active sites Multivariate statistical analysis Nickel catalysts ToF‐SIMS

More Related Videos

Imaging Corrosion at the Metal-Paint Interface Using Time-of-Flight Secondary Ion Mass Spectrometry

Imaging Corrosion at the Metal-Paint Interface Using Time-of-Flight Secondary Ion Mass Spectrometry

Published on: May 6, 2019

Synthesis and Performance Characterizations of Transition Metal Single Atom Catalyst for Electrochemical CO2 Reduction

Synthesis and Performance Characterizations of Transition Metal Single Atom Catalyst for Electrochemical CO2 Reduction

Published on: April 10, 2018

Related Experiment Videos

Last Updated: Jan 18, 2026

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions

In Situ SIMS and IR Spectroscopy of Well-defined Surfaces Prepared by Soft Landing of Mass-selected Ions

Published on: June 16, 2014

Imaging Corrosion at the Metal-Paint Interface Using Time-of-Flight Secondary Ion Mass Spectrometry

Imaging Corrosion at the Metal-Paint Interface Using Time-of-Flight Secondary Ion Mass Spectrometry

Published on: May 6, 2019

Synthesis and Performance Characterizations of Transition Metal Single Atom Catalyst for Electrochemical CO2 Reduction

Synthesis and Performance Characterizations of Transition Metal Single Atom Catalyst for Electrochemical CO2 Reduction

Published on: April 10, 2018

Area of Science:

Surface Science
Catalysis
Materials Science

Background:

Identifying active sites in heterogeneous catalysis is crucial but difficult, especially for complex materials.
Nanoscale characterization of ultrathin, chemically mixed surface layers presents unique challenges.

Purpose of the Study:

To develop a generalizable method for nanoscale active site identification in catalysis.
To correlate surface motifs with catalytic activity using advanced analytical techniques.

Main Methods:

Utilized time-of-flight secondary ion mass spectrometry (ToF-SIMS) for high-resolution surface analysis.
Applied multivariate statistical analysis, including principal component analysis (PCA) and multivariate curve resolution (MCR), to interpret ToF-SIMS data.
Employed density functional theory (DFT) calculations to understand the origin of catalytic activity.

Main Results:

PCA distinguished hydroxide-, oxide-, and metal-rich regions on nickel electrodes.
MCR resolved depth profiles and 3D images into distinct nanoscale layers (hydroxide, oxide, metallic).
A unique marker, NiO3H3-, was identified in hydroxide-rich areas and correlated with hydrogen evolution reaction (HER) activity.

Conclusions:

The combined ToF-SIMS and statistical analysis approach enables nanoscale resolution of catalytic active sites.
Ni(OH)2 clusters adjacent to metallic Ni were identified as key sites for water dissociation in HER.
This workflow transforms ToF-SIMS into a predictive tool for designing efficient catalysts.