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Panorama: a database for the oncogenic evaluation of somatic mutations in pan-cancer

Seung-Jin Park1, Seon-Young Kim1,2

  • 1Korea Research Institute of Bioscience and Biotechnology, Daejeon 34131, Republic of Korea.

Database : the Journal of Biological Databases and Curation
|January 16, 2026
PubMed

Insights

Panorama quantifies the oncogenic potential of single somatic mutations across all cancer types. This tool integrates proteogenomics data to identify driver mutations and potential drug targets, enhancing cancer research.

Area of Science:

  • Oncology
  • Genomics
  • Proteomics

Background:

  • Somatic mutations drive cancer development but their tissue-specific effects are understudied.
  • Previous pan-cancer studies have provided broad molecular landscapes but lacked focus on individual mutation impacts.
  • Understanding single somatic mutation effects across diverse tissues is crucial for targeted therapies.

Purpose of the Study:

  • To develop Panorama, a novel framework for evaluating the oncogenic potential of individual somatic mutations.
  • To assess mutation impacts on transcriptomes, proteomes, phosphoproteomes, tumor microenvironment, and signaling pathways.
  • To identify potential drug targets by analyzing downstream effects of somatic mutations.

Main Methods:

  • Collected and analyzed proteogenomics/multiomics data from over 10,000 cancer patients across 19 cancer types.
  • Developed five evaluation criteria to assess mutation effects on molecular layers and biological processes.
  • Utilized five oncogenic metrics to quantify mutation potential and identify driver mutations.

Main Results:

  • Panorama successfully quantifies the oncogenic potential of single somatic mutations.
  • The framework integrates downstream effects, providing a comprehensive view of mutation impact.
  • Identified potential drug targets through analysis of mutation-driven alterations.

Conclusions:

  • Panorama offers a robust framework for understanding somatic mutations in specific tissues.
  • The tool enhances the integration of cancer proteogenomics data for deeper insights.
  • Panorama is a freely accessible web-based database for the research community.

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