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Related Concept Videos

Aneurysm II: Clinical Manifestations and Diagnostic Studies01:21

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Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
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Related Experiment Video

Updated: Jan 18, 2026

Double Direct Injection of Blood into the Cisterna Magna as a Model of Subarachnoid Hemorrhage
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Subarachnoid hemorrhage: New insights on pathogenesis.

Divine C Nwafor1,2,3, Allison L Brichacek4, Michael S Rallo5

  • 1Department of Neuroscience, School of Medicine, West Virginia University Health Science Center, Morgantown, WV, United States.

Frontiers in Stroke
|January 16, 2026
PubMed
Summary

The gut microbiome may influence brain aneurysm development and rupture. Targeting inflammation offers a potential strategy to mitigate neurological damage from subarachnoid hemorrhage (SAH).

Keywords:
aneurysmdietintracranial hemorrhagemicrobiomeneuroinflammationsubarachnoid hemorrhage

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Area of Science:

  • Neurology
  • Microbiology
  • Vascular Biology

Background:

  • Subarachnoid hemorrhage (SAH) is a severe stroke type with high mortality.
  • Saccular intracranial aneurysms are the primary cause of SAH.
  • The role of the microbiome in SAH remains under-explored, unlike in ischemic stroke.

Purpose of the Study:

  • To review current knowledge on the microbiome's role in intracranial aneurysm formation and rupture.
  • To explore the influence of diet on aneurysm development.
  • To identify potential therapeutic strategies for SAH.

Main Methods:

  • Literature review of studies on the microbiome, diet, inflammation, and intracranial aneurysms.
  • Synthesis of current evidence linking gut dysbiosis to aneurysm pathogenesis.
  • Analysis of inflammatory pathways implicated in SAH.

Main Results:

  • Emerging evidence suggests the microbiome influences intracranial aneurysm formation and rupture.
  • Dietary factors significantly impact aneurysm development.
  • Inflammatory pathways are critical in SAH pathophysiology and neurological dysfunction.

Conclusions:

  • The gut microbiome represents a novel factor in intracranial aneurysm disease.
  • Dietary interventions and targeting inflammation are promising strategies for SAH prevention and treatment.
  • Further research is needed to elucidate the precise mechanisms linking the microbiome to SAH.