Prostaglandins, kinin and inflammation in the rat

1 Prostaglandin E(1) and bradykinin exert synergistic effects on vascular permeability in rat skin and in rat paws. Prostaglandin E(2) is inactive in this respect.2 Prostaglandin F(2alpha) reduces the bradykinin response in rat skin but not in rat paws. It also markedly reduces the response of the skin to dextran, 5-hydroxytryptamine and histamine.3 Prostaglandin E(1) and dextran exert synergistic effects in rat skin when threshold doses of each agent are used.4 Rats genetically resistant to dextran fail to respond to intradermal dextran in the presence of prostaglandin E(1).