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Relationship Between Cardiac Autonomic Control and Intradialytic Hypotension in Senegalese Chronic Hemodialysis

Ibrahima Lyra Sarr1, Abdou Khadir Sow2, Baratou Coundoul1

  • 1Department of Nephrology, Dialysis and Kidney Transplant, Ouakam Military Hospital, Dakar, Senegal.

Electrolyte & Blood Pressure : E & BP
|January 16, 2026
PubMed

Insights

Intradialytic hypotension (IDH) in hemodialysis patients was not strongly linked to cardiac autonomic neuropathy (CAN) based on heart rate variability (HRV) findings. Further research is needed to identify other risk factors for IDH.

Area of Science:

  • Nephrology
  • Cardiology
  • Neurology

Background:

  • Intradialytic hypotension (IDH) is a significant complication in chronic hemodialysis, increasing cardiovascular risks.
  • Cardiac autonomic neuropathy (CAN) is a potential contributing factor to IDH, affecting autonomic control of the heart.

Purpose of the Study:

  • To evaluate cardiac autonomic control in hemodialysis patients using heart rate variability (HRV).
  • To investigate the relationship between HRV, indicative of CAN, and the occurrence of IDH.

Main Methods:

  • A prospective study was conducted with 52 hemodialysis patients in Senegal.
  • Heart rate variability (HRV) was measured before, during, and after hemodialysis sessions.
  • Patients were categorized into three groups based on systolic blood pressure changes during dialysis.

Main Results:

  • Pre-dialysis, patients who experienced significant blood pressure drops (Group II) showed higher HRV frequency domain indices compared to other groups.
  • These patients also exhibited less severe cardiac autonomic neuropathy (CAN) pre-dialysis.
  • No significant differences in HRV parameters were observed among the groups post-dialysis.

Conclusions:

  • Heart rate variability (HRV) did not show a clear association with intradialytic hypotension (IDH) in this cohort.
  • The findings suggest that factors other than CAN, as assessed by HRV, may play a more significant role in IDH.
  • Further studies are recommended to explore alternative risk factors for IDH in hemodialysis patients.
Abstract

Keywords:
Autonomic nervous systemHeart rateHypotensionRenal dialysisSenegal

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