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Updated: Jan 18, 2026

Ultrasound-guided Botulinum Toxin-A Injections: A Method of Treating Sialorrhea
Published on: November 9, 2016
Ultrasound-guided injection of ankle contouring with botulinum neurotoxin
Kyu-Ho Yi1,2, Jin-Hyun Kim1, Jong-Keun Song3
1You and I Clinic, Seoul, Republic of Korea.
Background:
A slim ankle is considered a hallmark of beauty in modern aesthetics. Excessive muscular hypertrophy, particularly of the deep calf muscle (soleus), can lead to a thick ankle appearance that detracts from an overall refined leg contour. Although surgical approaches have been used historically, they carry risks such as scarring, contracture, and unpredictable outcomes.
Objective:
This study aimed to evaluate the efficacy and safety of ultrasound-guided botulinum toxin type A (JETEMA THE TOXIN, JETEMA Co., Ltd. Korea) injections for improving ankle contour in patients with thick ankles.
Methods:
Three adult female patients with noticeably hypertrophic calf muscles underwent ultrasound-guided injection of 20 units of botulinum toxin into the soleus muscles. Needles were inserted with ultrasound guidance to ensure precise real-time visualization and accurate injection into the soleus muscles. Ankle circumference and soleus muscle thickness were measured pre-treatment and at 8 weeks post-treatment using standardized methods. Wilcoxon signed-rank test was applied to evaluate statistical significance.The manuscript was checked against the Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) checklist (Supplemental Appendix).
Results:
All patients exhibited a reduction in ankle circumference (approximately 6.7-7.1 %) and soleus muscle thickness (around 14-15 %) at the 8-week follow-up. The Wilcoxon test revealed statistically significant differences (p = 0.001) between pre- and post-treatment values. Visual assessment of photographic records further confirmed a noticeably slimmer and more refined ankle contour.
Conclusion:
Ultrasound-guided botulinum toxin injections appear to be a safe and effective minimally invasive approach for ankle contouring, achieving clinically meaningful reductions in muscle bulk with high patient satisfaction.
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