A Potential Case of Acamprosate-Induced Syncope in an Elderly Patient: A Case Report and Literature Review

Acamprosate is commonly prescribed to maintain abstinence in patients with alcohol use disorder (AUD) and is generally well tolerated; however, syncope is not typically recognized as a potential adverse effect. We present the case of an elderly woman with no prior cardiac or neurological history who developed unexplained syncope shortly after initiating acamprosate. A comprehensive diagnostic workup was unremarkable. Acamprosate was discontinued, and no further episodes occurred during follow-up. Although a definitive causal relationship cannot be confirmed, the absence of other identifiable causes and the temporal association raise the possibility of a link between acamprosate and syncope. This case underscores a potentially unrecognized adverse effect of acamprosate, particularly relevant in elderly patients, and emphasizes the need for clinicians to be aware of this possible association.