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Urinary Podocyte Loss is Associated With Treatment Response in Patients With Primary Nephrotic Syndrome
Bartholomeus T van den Berge1,2, Jitske Jansen3, Quinty Leusink1
1Department of Nephrology, Radboud Institute for Molecular Life Sciences, Radboudumc, Nijmegen, The Netherlands.
Kidney International Reports
|January 16, 2026
Summary
Measuring urinary podocyte loss (podocyturia) can help predict treatment response in primary nephrotic syndrome (PNS). Elevated podocyturia levels in PNS patients normalize with remission, aiding prognosis.
Area of Science:
- Nephrology
- Immunology
- Pathology
Background:
- Primary nephrotic syndrome (PNS) presents a variable clinical course, making early prediction of treatment response challenging.
- PNS is characterized by podocyte injury and subsequent loss, a key factor in disease progression.
Purpose of the Study:
- To investigate the association between urinary podocyte loss (podocyturia) and treatment response in patients with primary nephrotic syndrome.
- To determine if quantitative podocyturia measurements can serve as a prognostic marker for PNS.
Main Methods:
- Inclusion of 59 PNS patients (minimal change disease [MCD], focal segmental glomerulosclerosis [FSGS], membranous nephropathy [MN]) and 21 controls.
- Analysis of urinary sediments for podocyte-specific markers using fluorescence-activated cell sorting (FACS) and correlation with clinical data.
Main Results:
- PNS patients exhibited significantly higher podocyturia levels compared to controls.
- Podocyturia levels correlated with proteinuria and normalized upon complete remission.
- Baseline podocyturia differentiated early vs. late responders in MCD/FSGS patients and was associated with spontaneous remission in MN patients.
Conclusions:
- Elevated podocyturia is a characteristic finding in primary nephrotic syndrome.
- Quantitative assessment of podocyturia holds prognostic value for predicting treatment outcomes in PNS.
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