Impact of Transcatheter Tricuspid Valve Repair on Pre- and Post-Procedural Hospitalization Rates.

Area of Science:

• Cardiology
• Interventional Cardiology
• Health Services Research

Background:

• Tricuspid regurgitation is a common complication of heart failure.
• Transcatheter edge-to-edge repair (TEER) is an emerging treatment for tricuspid regurgitation.
• The impact of tricuspid TEER on heart failure hospitalizations remains unclear.

Purpose of the Study:

• To evaluate the effectiveness of tricuspid TEER in reducing heart failure hospitalizations.
• To analyze real-world data on tricuspid TEER outcomes.
• To compare hospitalization rates before and after isolated or concomitant tricuspid and mitral TEER.

Main Methods:

• Retrospective analysis of Medicare and Medicaid data (2015-2019).
• Inclusion of 487 patients undergoing isolated tricuspid TEER or concomitant tricuspid and mitral TEER.
• Comparison of HF hospitalization rates using Poisson regression across four post-procedure time periods (1-365 days).

Main Results:

• Tricuspid TEER was associated with a significant reduction in HF hospitalizations (adjusted rate ratio 0.55, P < 0.001).
• This reduction was consistent when analyzing concomitant tricuspid and mitral TEER (adjusted rate ratio 0.57, P < 0.001).
• Patients experienced fewer HF hospitalizations in the year following the procedure.

Conclusions:

• Tricuspid TEER is an effective strategy for reducing heart failure hospitalizations in a real-world setting.
• The procedure demonstrates significant benefits for patients with tricuspid regurgitation, regardless of concomitant mitral valve intervention.
• These findings support the use of tricuspid TEER for managing heart failure complications.