Transcranial Doppler in 150 Congolese children with sickle cell disease
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View abstract on PubMed
Summary
This summary is machine-generated.In Congolese children with Sickle Cell Disease (SCD), 14% had abnormal Transcranial Doppler (TCD) results, indicating a high stroke risk. Early TCD screening is crucial for preventing stroke complications in these young patients.
Area Of Science
- Neurology
- Hematology
- Pediatrics
Background
- Sickle Cell Disease (SCD) is a prevalent global genetic disorder, with high incidence in sub-Saharan Africa.
- Stroke is a major cause of disability and mortality in SCD patients.
- Transcranial Doppler (TCD) is recommended for non-invasive stroke risk assessment in young SCD patients.
Purpose Of The Study
- To determine the prevalence of abnormal TCD findings in young Congolese SCD patients.
- To assess the association between pathological TCD results and hematological parameters.
Main Methods
- A cross-sectional study of 150 Congolese children (ages 2-16) with SCD in stable condition.
- TCD was performed using the STOP I method to measure mean maximum velocity in the middle cerebral artery (MCA).
- Stroke risk was categorized based on MCA velocity: normal (<170 cm/s), conditional (170-199 cm/s), and pathological (≥200 cm/s).
Main Results
- The prevalence of pathological TCD was 4%, and conditional TCD was 10%.
- A significant difference in WBC, Hb, Hct, and MCV was observed between normal and at-risk TCD groups.
- No significant association was found for categorical hematological parameters.
Conclusions
- Globally, 14% of the studied children were at risk of stroke.
- Integrating TCD into routine SCD monitoring is essential for stroke prevention.
- Interventions like chronic blood transfusions or hydroxycarbamide may mitigate stroke risk.
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