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Published on: March 17, 2020
Necrotizing gingival infection due to Trichoderma longibrachiatum in an hematopoietic stem cell transplant recipient:
Eduardo Aparicio-Minguijón1, Nieves López-Muñoz2, Pilar Martínez-Sánchez2,3
1Unit of Infectious Diseases, Hospital Universitario "12 de Octubre", Centro de Actividades Ambulatorias, 6ª planta, Bloque D. Glorieta de Málaga, 11., Madrid 28041, Spain.
Abstract:
Trichoderma is a genus of rare filamentous fungi that can cause invasive fungal infections in immunocompromised patients. We report a case of necrotizing gingival and sinus infection due to T. longibrachiatum in an allogeneic stem cell transplant recipient. The patient received a combination of antifungal and aggressive surgical debridement, achieving clinical cure. The treatment included amphotericin B, voriconazole and caspofungin with the latter switch to rezafungin to consolidate therapy. Rezafungin might represent a useful alternative for fungal infections with limited therapeutic options, but further studies are needed to confirm its role in Trichoderma spp. infections.
Insights
A rare fungal infection caused by Trichoderma longibrachiatum in an immunocompromised patient was successfully treated. Combination antifungal therapy and surgery led to a clinical cure, highlighting potential new treatment options.
Area of Science:
- Mycology
- Infectious Diseases
- Transplant Medicine
Background:
- Trichoderma is a rare filamentous fungus causing invasive infections in immunocompromised individuals.
- Invasive fungal infections pose significant risks to patients, particularly allogeneic stem cell transplant recipients.
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