Related Experiment Video
Updated: Jul 1, 2026

08:51
Monitoring Protein Adsorption with Solid-state Nanopores
Published on: December 2, 2011
14.0K
Single-molecule identification of full-length proteins with single-amino-acid resolution using nanopores
Biorxiv : the Preprint Server for Biology
|January 16, 2026
Abstract:
Nanopore-based technologies show promise in single-molecule protein sequencing. By using an unfoldase and a nanopore with enhanced electroosmotic flow, here we show the continuous identification of generic proteins during single nanopore passes. This approach enables the recording of differences in charge and size from single amino acid substitutions compared to reference signals, paving the way for single-molecule protein sequencing and high-throughput proteomics.

