Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

CNS Depressants: Alcohol and Nicotine01:27

CNS Depressants: Alcohol and Nicotine

1.0K
Ethanol, a clear colorless alcohol, has been consumed by humans for millennia, but its effects on the body are far from benign. At lower doses, it induces decreased inhibitions and loquaciousness, leading to its social appeal. However, it can cause severe consequences at higher doses, such as coma and respiratory depression, due to its zero-order elimination kinetics. Chronic ethanol abuse wreaks havoc on multiple organ systems, particularly the CNS and the liver. Abrupt cessation of ethanol...
1.0K
Substance Use Disorders Affecting Sleep01:24

Substance Use Disorders Affecting Sleep

403
Substance use disorders involve a pattern of using drugs more extensively than intended and continuing use despite harmful consequences. This includes legal substances like alcohol and nicotine, as well as illegal drugs. These disorders often involve both physical and psychological dependence, reflecting compulsive use of substances that significantly alter thoughts, feelings, and behaviors, contributing to a major public health issue.
Understanding the concepts of physical dependence,...
403
Depressants01:28

Depressants

384
Depressant drugs, including alcohol and sedative-hypnotics, diminish central nervous system activity by enhancing the action of gamma-aminobutyric acid (GABA), a neurotransmitter that reduces brain activity and promotes relaxation. These substances can have various therapeutic uses but also pose significant risks, especially when misused or combined.
Alcohol is a common depressant that can induce a sense of relaxation and reduced inhibition at low doses. Contrary to its occasional...
384
Drugs Affecting Neurotransmitter Synthesis01:29

Drugs Affecting Neurotransmitter Synthesis

2.1K
Drugs affecting neurotransmitter synthesis can impact the adrenergic neuron and the synthesis of neurotransmitters. For example, α-methyltyrosine and carbidopa target specific enzymes involved in catecholamine synthesis. α-methyltyrosine inhibits the enzyme tyrosine hydroxylase, which converts tyrosine into dopamine. By blocking this enzyme, α-methyltyrosine reduces dopamine production and other catecholamines. Carbidopa, on the other hand, inhibits the enzyme dopa decarboxylase,...
2.1K
An Overview of Psychoactive Drugs01:28

An Overview of Psychoactive Drugs

583
Psychoactive drugs impact brain function, influencing perception, mood, consciousness, cognition, and behavior. These substances are grouped based on their effects and the mechanisms by which they act.
Stimulants such as cocaine, amphetamines, and nicotine enhance brain activity, leading to increased alertness, attention, and energy. These drugs typically raise heart rate, blood pressure, and body temperature. While they can induce feelings of euphoria, their misuse can result in severe health...
583
The Periodic Table and Organismal Elements00:57

The Periodic Table and Organismal Elements

200.0K
Overview
200.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multi-omics profiling reveals EMT-driven fibroblast activation in the renal injury niche.

Cellular and molecular life sciences : CMLS·2026
Same author

How does type 2 diabetes modify the risk of Alzheimer's disease?

Alzheimer's & dementia : the journal of the Alzheimer's Association·2026
Same author

Isolation and Identification of Bacillus velezensis G52 and Its Growth-Promoting Mechanism on Navel Orange Seedlings.

Cell biochemistry and function·2026
Same author

From Chemical Discrepancy to Mechanistic Insight: UPLC-MS, Bioinformatics, and In Vivo Studies on the Anti-Brain Aging Effects of Polygalae Radix and Its Processed Products.

Biomedical chromatography : BMC·2026
Same author

Pial arteriovenous fistula following aneurysm clipping: a case report of a rare complication.

Acta neurochirurgica·2026
Same author

Cannabidiol dose modulates behavioral response to acute and repeated administration of Δ9-Tetrahydrocannabinol by strain and sex.

bioRxiv : the preprint server for biology·2026
Same journal

Layered social competition coordinates reproductive hierarchy formation in ants.

bioRxiv : the preprint server for biology·2026
Same journal

Combination epigenetic-targeted therapy increases the immunogenicity of poorly immunogenic sarcomas.

bioRxiv : the preprint server for biology·2026
Same journal

Loss of LanC-like proteins delays post-injury regeneration of aging skeletal muscles.

bioRxiv : the preprint server for biology·2026
Same journal

Integrative Transfer Network: Deep Transfer Learning Across Populations and Prediction Targets.

bioRxiv : the preprint server for biology·2026
Same journal

Confidence-supported label-free metabolic imaging with FPhaS phase autofluorescence microscopy.

bioRxiv : the preprint server for biology·2026
Same journal

Sequence-encoded autoinhibition couples mRNA decapping activity to phase separation.

bioRxiv : the preprint server for biology·2026
See all related articles

Related Experiment Video

Updated: Jan 18, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

22.0K

Alcohol Use Disorder Affects Brain Metals.

Byron C Jones1,2, Wenyuan Zhao1, Julia Stevens3

  • 1Department of Genetics, Genomics, and Informatics, College of Medicine, University of Tennessee Health Science Center, Memphis, Tennessee.

Biorxiv : the Preprint Server for Biology
|January 16, 2026
PubMed
Summary
This summary is machine-generated.

Alcohol use disorder (AUD) alters brain iron levels, potentially contributing to dementia. This study found significant changes in iron and other metals in brain tissues of individuals with AUD, particularly in females.

Keywords:
caudate nucleuscopperironsubstantia nigrazinc

More Related Videos

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.4K
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
19:57

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

8.8K

Related Experiment Videos

Last Updated: Jan 18, 2026

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication
09:26

Disruption of Frontal Lobe Neural Synchrony During Cognitive Control by Alcohol Intoxication

Published on: February 6, 2019

22.0K
Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder
05:12

Chronic Intermittent Ethanol Vapor Exposure Paired with Two-Bottle Choice to Model Alcohol Use Disorder

Published on: June 23, 2023

1.4K
The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders
19:57

The Use of Trace Eyeblink Classical Conditioning to Assess Hippocampal Dysfunction in a Rat Model of Fetal Alcohol Spectrum Disorders

Published on: August 5, 2017

8.8K

Area of Science:

  • Neuroscience
  • Toxicology
  • Biochemistry

Background:

  • Alcohol use disorder (AUD) is linked to dementia, with potential mechanisms involving brain iron dysregulation.
  • Excessive iron can cause oxidative stress and neuronal damage, leading to ferroptosis (iron-related cell death).
  • Understanding AUD's impact on brain iron homeostasis is crucial for elucidating dementia pathology.

Purpose of the Study:

  • To investigate the hypothesis that AUD causes brain iron dysregulation.
  • To quantify iron concentrations in specific brain regions (hippocampus, caudate, substantia nigra) in AUD individuals.
  • To compare metal concentrations between AUD and control groups.

Main Methods:

  • Brain tissues (hippocampus, caudate, substantia nigra) were obtained from 40 individuals (20 AUD, 20 controls).
  • Tissues were analyzed for iron, copper, and zinc content using total x-ray reflectance fluorescence.
  • Analysis included both male and female participants, with equal representation from AUD and control groups.

Main Results:

  • Hippocampus showed decreased iron in AUD individuals.
  • Substantia nigra exhibited increased iron (females) and decreased iron/zinc (males).
  • Caudate displayed significantly increased iron and copper in females, and increased copper in males.

Conclusions:

  • AUD significantly dysregulates trace metal concentrations in the brain.
  • Observed metal changes suggest a role in AUD-related neurodegeneration.
  • Gender-specific differences in metal dysregulation were noted, potentially linked to alcohol metabolism.