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Related Concept Videos

Obsessive-Compulsive Disorder01:28

Obsessive-Compulsive Disorder

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Obsessive-compulsive disorder (OCD) is a mental health condition characterized by recurrent obsessions, compulsions, or both, which consume significant time and interfere with daily functioning. Obsessions involve persistent, intrusive, and unwanted thoughts, images, or urges that evoke anxiety. Common examples include irrational fears of contamination or harm. Compulsions are repetitive behaviors or mental acts performed to reduce the anxiety caused by obsessions. For instance, individuals...
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Behavior genetics explores how genetic inheritance influences human behavior. It focuses on how genes, passed from parents to offspring, contribute to the development of behavioral traits and tendencies. This branch of genetics seeks to understand the complex interplay between inherited genetic factors and environmental influences in shaping our behaviors.
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Human genetics provides a profound framework for understanding the interplay between genetic predispositions and human psychology. At the heart of this discipline lies the study of how genes influence physical traits, behaviors, and susceptibility to diseases. Each person carries a unique genetic code that subtly or significantly shapes their psychological and behavioral landscape.
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Related Experiment Video

Updated: Jan 18, 2026

Exploring the Neural Correlates of Cognitive Reappraisal in Obsessive-Compulsive Disorder Using Task-based Functional Magnetic Resonance Imaging
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Black EquaLity in OCD NeuroGenomics (BELONG): Study Protocol.

Iasha J Williams, Dalia Y Marquez, Kara E Lopez-Lengowski

    Medrxiv : the Preprint Server for Health Sciences
    |January 16, 2026
    PubMed
    Summary

    The Black EquaLity in OCD NeuroGenomics (BELONG) study aims to improve obsessive-compulsive disorder (OCD) genetic research by collecting data from 1,250 Black Americans. This initiative seeks to identify OCD risk genes and advance precision medicine for diverse populations.

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    Area of Science:

    • Psychiatric Genetics
    • Neurogenomics
    • Population Genetics

    Background:

    • Obsessive-compulsive disorder (OCD) affects 2-3% of the population, with genetic factors contributing significantly to risk.
    • Current genomic studies for OCD are limited by a lack of diversity, primarily including participants of European ancestry.
    • This underrepresentation hinders the generalizability of findings and the development of precision medicine for all affected individuals.

    Purpose of the Study:

    • To establish the Black EquaLity in OCD NeuroGenomics (BELONG) study, focusing on collecting data from 1,250 Black Americans with OCD.
    • To increase the representation of African ancestry in OCD genetic research.
    • To identify common and rare genetic variants associated with OCD risk and potential therapeutic targets.

    Main Methods:

    • Collecting DNA and detailed clinical data from 1,250 OCD cases of African ancestry, including parental samples for trio analyses.
    • Utilizing optimized DNA sequencing approaches to analyze both rare and common genome-wide variations.
    • Performing meta-analysis with existing OCD genomic datasets to enhance statistical power.

    Main Results:

    • The BELONG study is actively collecting data to build a large, well-characterized cohort of Black Americans with OCD.
    • Sequencing data will enable comprehensive analysis of genetic variations contributing to OCD.
    • Meta-analysis will integrate findings with existing research to identify robust OCD risk genes.

    Conclusions:

    • The BELONG study is crucial for diversifying OCD genetic research and ensuring findings are applicable to Black Americans.
    • Increased representation is essential for advancing precision medicine in psychiatric genetics.
    • This research will contribute to a more comprehensive understanding of OCD etiology and facilitate the development of targeted therapies.