Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Opioid Analgesics: Synthetic and Semisynthetic Opioids01:15

Opioid Analgesics: Synthetic and Semisynthetic Opioids

931
Synthetic and semisynthetic opioids are pivotal in pain management and tackling opioid addiction. Semisynthetic opioids, including morphinans (morphine derivatives), oxycodone, oxymorphone, hydrocodone, and hydromorphone, have improved pharmacokinetic profiles compared to morphine. Additionally, heroin and 6-MAM (6-Monoacetylmorphine) show better CNS penetration than morphine due to heightened lipid solubility. Hydromorphone, a potent opioid, undergoes hepatic metabolism to form the active...
931
Opioid Analgesics: Morphine and Other Natural Cogeners01:20

Opioid Analgesics: Morphine and Other Natural Cogeners

865
Opioids are a class of drugs that mimic endogenous opioid peptides and act on opioid receptors, and help in pain relief. These compounds are classified as natural, synthetic, or semi-synthetic. Natural opioids, like morphine, codeine, and thebaine, are derived from the opium poppy plant (Papaver somniferum or Papaver album) and are termed opiates. Synthetic opioids are artificial, while semi-synthetic opioids combine natural and synthetic compounds. Morphine, a prototypical opioid, possesses a...
865
Parenteral Anesthetics: Overview01:24

Parenteral Anesthetics: Overview

610
Intravenous anesthetics are drugs administered parenterally to induce anesthesia or sedation. Propofol is a widely used agent formulated as a 1% emulsion in soybean oil, glycerol, and egg phosphatide. It induces rapid anesthesia primarily due to its rapid distribution from the bloodstream to target tissues and is metabolized in the liver. However, it can cause significant pain on injection and hypertriglyceridemia. Fospropofol, a water-based prodrug of propofol, lacks these adverse effects.
610
Analgesia and Pain Management01:25

Analgesia and Pain Management

1.5K
Pain is critical to various clinical pathologies, provoking an urgent need for effective management. Pain, whether acute or chronic, is a complex neurochemical process. Its alleviation depends on the type, with nonopioid analgesics effective for mild to moderate pain, such as musculoskeletal or inflammatory pain, while neuropathic pain responds best to anticonvulsants, tricyclic antidepressants, or serotonin/norepinephrine reuptake inhibitors. For severe acute or chronic pain, opioids may be...
1.5K
Local Anesthetics: Clinical Application as Epidural Anesthesia01:29

Local Anesthetics: Clinical Application as Epidural Anesthesia

687
Epidural anesthetics are administered in the fat-filled epidural space, the outermost part of the spinal canal. This technique is commonly employed for pain management and anesthesia during lower abdomen and pelvis surgeries or labor and delivery.
Since epidural anesthetics can be infused through an epidural catheter, all types of drugs, including short-acting ones, can be administered. Chloroprocaine and lidocaine are examples of short and long-duration anesthetics, respectively. Bupivacaine...
687
Opioid Receptors: Overview01:22

Opioid Receptors: Overview

4.1K
Opioid receptors, including the mu (μ, MOR), delta (δ, DOR), and kappa (κ, KOR) types, belong to the rhodopsin family of G protein-coupled receptors. These receptors are located throughout the central and peripheral nervous systems and in non-neuronal tissues such as macrophages and astrocytes. Opioid receptor ligands can be categorized into agonists or antagonists. Highly selective agonists include [d-Ala2, MePhe4, Gly(ol)5]-enkephalin or DAMGO for MOR, [D-Pen2,...
4.1K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Parental Perspectives on Using the FLACC Scale for Postoperative Pain at Home After Orchiopexy.

Paediatric anaesthesia·2026
Same author

Analgesic efficacy and functional outcomes of 10 versus 20 mL bupivacaine for popliteal plexus block after total knee arthroplasty: a randomized clinical trial.

Regional anesthesia and pain medicine·2026
Same author

Impact of Intraoperative Clonidine on Postoperative Opioid Use in Patients With Endometriosis: A Randomized Controlled Trial.

A&A practice·2025
Same author

Chronic pain after primary total and medial unicompartmental knee arthroplasty for osteoarthritis: a Danish nationwide cross-sectional survey.

Acta orthopaedica·2025
Same author

Chronic Postsurgical Pain after Primary Total Hip Arthroplasty for Osteoarthritis: A Nationwide Cross-Sectional Survey Study.

The Journal of arthroplasty·2025
Same author

Predicting acute postsurgical pain in the postanesthesia care unit: risk tool development and internal validation.

Pain reports·2025
Same journal

The evolution of nonoperating room anesthesia: navigating a new frontier.

Current opinion in anaesthesiology·2026
Same journal

Enhanced recovery pathways for patients with chronic pain: beyond standard protocols - a narrative review.

Current opinion in anaesthesiology·2026
Same journal

Novel technologies and innovations in postoperative follow-up after regional anesthesia.

Current opinion in anaesthesiology·2026
Same journal

Regional anaesthesia and analgesia in surgical patients with chronic preoperative pain: mechanisms, evidence, and clinical implications.

Current opinion in anaesthesiology·2026
Same journal

Retention in pain care and research: a narrative review focused on implanted medical devices.

Current opinion in anaesthesiology·2026
Same journal

Airway ultrasound in patients undergoing head and neck surgery.

Current opinion in anaesthesiology·2026
See all related articles

Related Experiment Video

Updated: Jan 18, 2026

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

11.2K

Intraoperative methadone: promise and pitfalls.

Fie Juul Praastrup1, Lone Nikolajsen1,2, Camilla Gaarsdal Uhrbrand1,3

  • 1Department of Anesthesiology, Aarhus University Hospital.

Current Opinion in Anaesthesiology
|January 16, 2026
PubMed
Summary
This summary is machine-generated.

Intraoperative methadone offers extended postoperative pain relief due to its long half-life and dual receptor activity. While generally safe, careful patient selection is advised for optimal outcomes in perioperative pain management.

Keywords:
analgesiaintraoperative methadonepostoperative painsafety

More Related Videos

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.7K
Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
06:44

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

8.0K

Related Experiment Videos

Last Updated: Jan 18, 2026

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury
07:07

Inducing Post-Traumatic Epilepsy in a Mouse Model of Repetitive Diffuse Traumatic Brain Injury

Published on: February 10, 2020

11.2K
A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration
09:16

A General Method for Evaluating Deep Brain Stimulation Effects on Intravenous Methamphetamine Self-Administration

Published on: January 22, 2016

15.7K
Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging
06:44

Modeling Brain Metastases Through Intracranial Injection and Magnetic Resonance Imaging

Published on: June 7, 2020

8.0K

Area of Science:

  • Anesthesiology and Pain Management
  • Pharmacology
  • Clinical Evidence Synthesis

Background:

  • Intraoperative methadone is evaluated for its role in multimodal perioperative pain management.
  • Recent clinical evidence from meta-analyses and RCTs is synthesized.

Purpose of the Study:

  • To summarize clinical evidence on intraoperative methadone.
  • To emphasize its analgesic efficacy and safety profile.
  • To assess its potential role in multimodal perioperative strategies.

Main Methods:

  • Review of meta-analyses and randomized controlled trials.
  • Focus on studies published within the past 18 months.
  • Analysis of analgesic efficacy, safety, and opioid-sparing effects.

Main Results:

  • Methadone's long half-life and dual receptor activity provide extended postoperative analgesia.
  • Opioid-sparing effects are variable, influenced by procedure, comparators, and multimodal context.
  • Safety is reassuring, with no increased risk of respiratory depression and rare QT prolongation at standard doses.
  • Intermediate dosing (0.15-0.25 mg/kg) balances analgesia and recovery.

Conclusions:

  • Intraoperative methadone is a valuable adjunct for perioperative pain management, particularly in high-pain procedures.
  • Efficacy is noted in ambulatory and pediatric surgery.
  • Safety is comparable to other opioids, but careful patient selection is necessary due to variable pharmacokinetics and potential for delayed recovery.