Related Experiment Video
Updated: Jan 18, 2026
06:15
Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus
Published on: March 6, 2019
51.9K
Clinical Factors Associated with Postnatal Urinary Titin N-Fragment in Neonates
Clinical Laboratory
|January 16, 2026
Summary
Urinary N-terminal titin (N-titin) shows promise as a neonatal biomarker for muscle injury and perinatal stress, especially in cases of asphyxia. Establishing reference values could aid early detection in newborns.
Area of Science:
- Biochemistry
- Neonatology
- Biomarker Discovery
Background:
- Titin is a crucial sarcomeric protein for muscle function.
- Urinary N-terminal titin (N-titin) is a recognized biomarker for adult muscle injury.
- The utility of N-titin in neonates requires further investigation.
Purpose of the Study:
- To investigate the clinical significance of urinary N-titin in neonates.
- To explore associations between N-titin levels and neonatal/maternal factors.
- To establish reference values for neonatal N-titin.
Main Methods:
- Retrospective cohort study of 523 neonates.
- Urinary N-titin/creatinine (N-titin/Cr) measured by ELISA within 24 hours of birth.
- Analysis of neonatal, maternal, and delivery factors; subgroup analysis for asphyxia.
Main Results:
- N-titin/Cr negatively correlated with gestational age and Apgar score.
- Positive correlations observed with AST, ALT, LDH, CK, and lactate.
- Higher N-titin/Cr associated with perinatal stress indicators like asphyxia, non-reassuring fetal status, and emergency C-section.
Conclusions:
- Urinary N-titin levels indicate acute perinatal stress in neonates, particularly asphyxia.
- Established reference values may facilitate N-titin's use as an early neonatal biomarker.
- Further research is warranted to validate N-titin's role in neonatal care.
Related Concept Videos
01:29Acute Kidney Injury II: Pathophysiology
903
Acute kidney injury (AKI) causes are categorized into three primary categories based on the location of the injury: prerenal, intrarenal (or intrinsic), and postrenal causes. This classification guides clinical management and illustrates how different pathways can impair kidney function.Etiology and Pathophysiology of Acute Kidney Injury1. Prerenal causesEtiology: Prerenal Acute Kidney Injury, the most common type, occurs when reduced blood flow to the kidneys decreases filtration capacity...
903
01:28Urinary Tract Calculi I: Introduction
411
Renal calculi, or kidney stones, are solid deposits of minerals and salts formed inside the kidneys. In medical terminology, "calculus" refers to the stone itself, while "lithiasis" describes the process of stone formation. Depending on their location within the urinary system, these stones may be classified as either urolithiasis, when situated within the urinary tract, or nephrolithiasis, when located within the kidneys. Each term signifies the specific impact of the stone.Predisposition...
411
01:26Urinary Tract Calculi II: Pathophysiology and Clinical Manifestations
373
Renal calculi, commonly termed kidney stones, are crystalline solid masses that form in the kidneys but can occur at any point within the urinary system, encompassing the kidneys, ureters, bladder, and urethra.The pathophysiology of renal stones involves several key factors: supersaturation of the urine with stone-forming constituents, changes in urine pH, a decrease in urine volume, and the presence of substances that promote or inhibit stone formation.Supersaturation of Urine: This is the...
373
01:25Urinary Tract Infection II: Pathophysiology
570
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
570
01:26Nephrotic Syndrome II : Assessment and Medical Management
203
IntroductionNephrotic syndrome is a kidney disorder marked by excessive protein loss in the urine, leading to various systemic complications. This condition often results from damage to the glomeruli—the kidney's filtering units—causing proteinuria, low blood protein levels, and fluid retention. Understanding the assessment, diagnosis, and management of nephrotic syndrome is essential for effective treatment and prevention of further kidney damage.AssessmentPatient History: Document...
203
01:24Nephrotic Syndrome I : Introduction
504
Nephrotic Syndrome is a chronic kidney disorder defined by clinical findings such as severe proteinuria, hypoalbuminemia, hyperlipidemia, and edema. These symptoms result from damage to the glomeruli, the kidney’s filtering units, increasing their permeability to proteins.Definition and Meaning:Proteinuria, defined as the loss of more than 3.5 grams of protein per day in adults, is a crucial feature of nephrotic syndrome. This condition is often accompanied by edema, the accumulation of...
504