Related Experiment Video
Updated: Jan 18, 2026
Author Spotlight: Detection and Treatment of Helicobacter pylori Infection
Published on: July 28, 2023
Can Serum C-Reactive Protein/Albumin Ratio be Used as a Marker of Chronic Helicobacter Pylori Infection?
Background:
Helicobacter pylori (H. pylori) is a Gram-negative bacterial agent that colonizes the gastric mucosa and leads to chronic infections. Various techniques are available for the detection of H. pylori; however, many of these methods are invasive, costly, and can only be performed in tertiary laboratories. It is necessary to find cost-effective and non-invasive novel indicators that can identify H. pylori infection and its activity.
Objective:
The objective of this study was to investigate the correlation between the CRP/albumin ratio (CAR), which is frequently analyzed in laboratory settings, and the presence of H. pylori, as well as the activation of H. pylori infection.
Methods:
The medical records of patients who had upper gastrointestinal endoscopy at our hospital were reviewed retrospectively. The data were analyzed using suitable tests with the IBM SPSS 27 software.
Results:
The study included 613 patients, comprising 375 females (61.2%) and 238 males (38.8%). Among the participants, 327 (53.3%) tested positive for H. Pylori, while 286 (46.7%) tested negative. All patients presented with dyspeptic symptoms, and other indications for UGISE included anemia, gastroesophageal reflux, epigastric discomfort, dysphagia, nausea and vomiting, bleeding, and scanning. Upon comparing the laboratory results of H. pylori-positive and -negative patients, no significant change in CRP values was observed (p > 0.05). The albumin level was statistically considerably elevated in H. pylori-negative pa-tients relative to -positive patients (p = 0.009). The CAR in H. pylori-positive patients was statistically substantially elevated compared to negative ones (p = 0.04).
Conclusions:
We assert that CAR may serve as a valuable biomarker for confirming the presence of H. pylori infection and for reflecting the systemic inflammatory status of patients.
Insights
The CRP/albumin ratio (CAR) may indicate Helicobacter pylori infection. Elevated CAR levels were observed in patients with H. pylori, suggesting its potential as a non-invasive biomarker for infection.
Area of Science:
- Gastroenterology
- Infectious Diseases
- Clinical Chemistry
Background:
- Helicobacter pylori (H. pylori) is a common bacterial cause of gastric inflammation.
- Current detection methods for H. pylori are often invasive and costly.
- There is a need for cost-effective, non-invasive biomarkers for H. pylori detection.
Purpose of the Study:
- To evaluate the CRP/albumin ratio (CAR) as a potential biomarker for H. pylori infection.
- To assess the correlation between CAR and H. pylori presence and activity.
Main Methods:
- Retrospective review of medical records from patients undergoing upper gastrointestinal endoscopy.
- Analysis of laboratory data, including C-reactive protein (CRP) and albumin levels.
- Statistical analysis using IBM SPSS 27 software.
Main Results:
- The study included 613 patients; 53.3% tested positive for H. pylori.
- No significant difference in CRP levels between H. pylori-positive and negative patients.
- Albumin levels were lower in H. pylori-positive patients (p=0.009).
- The CAR was significantly elevated in H. pylori-positive patients (p=0.04).
Conclusions:
- The CRP/albumin ratio (CAR) may serve as a valuable biomarker for H. pylori infection.
- CAR can potentially reflect the systemic inflammatory status in patients with H. pylori.
More Related Videos
03:47Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
Published on: November 1, 2024
05:23Gastric Mucosa Quantitative Polymerase Chain Reaction Analysis for Detecting Helicobacter pylori and Antibiotic Resistance
Published on: March 7, 2025
Related Concept Videos
01:19Blood Studies for Cardiovascular System II: CRP, Hcy, and Cardiac Natriuretic Peptide Markers
These markers indicate stress or strain on the heart muscle:
Natriuretic Peptides (BNP)
Cardiac myocytes produce these hormones in response to ventricular stretching...
01:28Peptic Ulcer Disease III: Clinical Manifestations and Diagnostic Studies
Few clinical manifestations differentiate gastric ulcers from duodenal ulcers. Distinctions in the location, timing, and pain relief are crucial for healthcare providers in differentiating between gastric and duodenal ulcers during clinical assessments.
01:16Treating Helicobacter pylori in Peptic Ulcers: Antimicrobial Therapy
01:24Serum Studies: Renal Function Tests
01:17Gastritis-II: Pathophysiology
In acute gastritis, the gastric mucosa becomes swollen and red and undergoes superficial erosion. Superficial ulceration may lead to bleeding.
In chronic gastritis, persistent or repeated insults lead to chronic inflammatory changes and, eventually, thinning or atrophy of the gastric tissue.
Gastritis can stem from various causes, each...
01:23Gastritis III: Clinical Manifestations and Management
Clinical manifestations of acute gastritis
The patient with acute gastritis may have a rapid onset of symptoms, such as epigastric pain or discomfort, dyspepsia, anorexia, hiccups, or nausea and vomiting, which can last from a few hours to a few days. Erosive or hemorrhagic gastritis may cause bleeding, which may manifest as blood in vomit or as...