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[Corrigendum] CDKN2A (p16INK4A) affects the anti‑tumor effect of CDK inhibitor in somatotroph adenomas
Yiyuan Chen1, Zhenye Li2, Qiuyue Fang1
1Department of Cell Biology, Beijing Neurosurgical Institute, Capital Medical University, Beijing 100070, P.R. China.
Abstract:
Following the publication of the above article and an expression of concern statement (doi: 10.3892/ijmm.2025.5680) after it had been drawn to the Editor's attention by an interested reader that, regarding the western blot data shown in Fig. 5 on p. 507, the first set of GAPDH bands for the GH3 cell line were strikingly similar to the EGFR protein bands shown for the GT1‑1 cell line in the adjacent set of gels, the authors have now replied to the Editorial Office to explain the apparently anomalous appearance of this figure. After having examined their original data, the authors have realized that this figure was assembled incorrectly; essentially, the wrong data were included in this figure to portray the GAPDH bands for the GH3 cell line. The revised version of Fig. 5, now showing the correct GAPDH data for the GH3 cell line, is featured on the next page. The authors can confirm that the error made during the assembly of Fig. 5 did not have a significant impact on either the results or the conclusions reported in this study, and all the authors agree with the publication of this Corrigendum. The authors are grateful to the Editor of International Journal of Molecular Medicine for allowing them the opportunity to publish this Corrigendum; furthermore, they apologize to the readership of the Journal for any inconvenience caused. [International Journal of Molecular Medicine 47: 500‑510, 2021; DOI: 10.3892/ijmm.2020.4807]
.Insights
A figure error in a molecular medicine study was corrected. The authors confirm the western blot data error for GAPDH in GH3 cells did not impact overall findings or conclusions.
Area of Science:
- Molecular Biology
- Cell Biology
- Biochemistry
Background:
- An expression of concern was issued regarding western blot data in Fig. 5.
- A reader noted similarities between GAPDH bands (GH3 cells) and EGFR bands (GT1-1 cells).
Purpose of the Study:
- To address the concern regarding the accuracy of western blot data presented in Fig. 5.
- To provide a corrected figure with accurate GAPDH data for the GH3 cell line.
Main Methods:
- Review of original experimental data.
- Correction and reassembly of Fig. 5 using appropriate western blot data.
Main Results:
- The original Fig. 5 incorrectly included western blot data for GAPDH in GH3 cells.
- A revised Fig. 5 with the correct GAPDH data for GH3 cells has been prepared.
Conclusions:
- The error in Fig. 5 assembly did not significantly affect the study's results or conclusions.
- The authors apologize for any inconvenience caused by the data presentation error.
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