PhI(OCOCF3)2-mediated metal-free 2,3-difunctionalization of indoles: direct access to carbochalcogenated scaffolds
Satyajit Pal1, Subhankar Sarkar1, Tanmay Pramanik1
1Department of Chemistry, Visva-Bharati (A Central University), Santiniketan, 731235, West Bengal, India. adinath.majee@visva-bharati.ac.in.
Abstract:
We report a metal-free approach for the oxidative difunctionalization of indole moieties using a hypervalent iodine reagent. This protocol facilitates a metal-free, environmentally friendly, and efficient oxidative C(sp2)-H coupling reaction that utilises indole, naphthoquinones, and diphenyl dichalcogenides. The method has been designed so that it should run under mild conditions to enable the formation of C(sp2)-C and C(sp2)-S/Se bonds with good yields and a wide range of relevant substrates. Additionally, our approach offers a valuable pathway for the modification of drug molecules, which further enhances its utility in organic synthesis.
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