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Two'-Fucosyllactose, a Human Milk Oligosaccharide, Promotes Intestinal Remodeling and Enhances Nutrient and

Sho Nishikawa1, Hidetoshi Yamada1, Yuto Funasaki1

  • 1Department of Life and Health Sciences, Teikyo University of Science, Uenohara-shi, Yamanashi, Japan.

Molecular Nutrition & Food Research
|January 16, 2026
PubMed
Summary
This summary is machine-generated.

2'-Fucosyllactose (2'FL) enhances nutrient absorption by promoting small intestine remodeling in mice. This human milk oligosaccharide shows potential for growth promotion and disease prevention.

Keywords:
2′‐fucosyllactosehuman milk oligosaccharidenutrient absorptionsmall intestine

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Area of Science:

  • Nutrition Science
  • Gastroenterology
  • Human Milk Oligosaccharides

Background:

  • 2 -Fucosyllactose (2 'FL) is a key human milk oligosaccharide with known biological benefits.
  • Investigating 2 'FL's impact on intestinal structure and function is crucial for understanding its role in health.

Purpose of the Study:

  • To determine the effects of 2 'FL supplementation on small intestinal remodeling.
  • To assess the consequent enhancement of nutrient and functional compound absorption capabilities.

Main Methods:

  • Oral supplementation of mice with 2 'FL daily for 20 days.
  • Evaluation of small intestine length, villi density, and intestinal barrier function.
  • Lipid tolerance tests and co-administration studies with specific compounds (CL316,243, curcumin).

Main Results:

  • Significant increase in small intestine length and villi density without compromising intestinal barrier function.
  • Enhanced absorption of docosahexaenoic acid-containing triglycerides, CL316,243, and curcumin.
  • Elevated uncoupling protein 1 levels in inguinal adipose tissue observed.

Conclusions:

  • 2 'FL promotes intestinal remodeling, leading to enhanced absorption of nutrients and functional compounds.
  • Highlights a novel role for 2 'FL in supporting intestinal health as a non-nutritive compound.
  • Suggests potential applications in growth promotion, lifestyle disease prevention, and frailty reduction.