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Complete genomes of Phascolarctobacterium faecium isolates obtained from pediatric mucosal-luminal interface aspirate

Gillian Tanabe1,2, David R Mack3,4, Alain Stintzi1,2

  • 1School of Pharmaceutical Sciences, University of Ottawa, Ottawa, Canada.

Microbiology Resource Announcements
|January 16, 2026
PubMed

Insights

Phascolarctobacterium faecium, a gut bacterium, is less common in Crohn's disease patients. This study presents the full genome sequences of two P. faecium strains from pediatric gut samples, aiding further research into inflammatory bowel disease.

Area of Science:

  • Microbiology
  • Genomics
  • Human Gut Microbiome

Background:

  • Phascolarctobacterium faecium is a common human gut commensal.
  • Reduced abundance of P. faecium has been observed in individuals with Crohn's disease, a chronic inflammatory bowel disease.

Purpose of the Study:

  • To sequence and characterize the complete genomes of two P. faecium strains.
  • To provide genomic resources for understanding the role of P. faecium in the gut microbiome, particularly in the context of Crohn's disease.

Main Methods:

  • Isolation of P. faecium strains from mucosal-luminal interface samples.
  • Whole-genome sequencing of the isolated strains.
  • Bioinformatic analysis of the obtained genome sequences.

Main Results:

  • Complete genome sequences for two P. faecium strains were successfully obtained.
  • These genomic data provide a foundation for comparative genomic studies.

Conclusions:

  • The availability of these P. faecium genomes facilitates future research into the bacterium's function and its association with Crohn's disease.
  • Further investigation is warranted to elucidate the specific mechanisms underlying P. faecium's altered abundance in Crohn's disease patients.

Keywords:
Crohn's diseasePhascolarctobacterium faeciumgut microbiomemucosal-luminal interface

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