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Related Concept Videos

Esophageal Varices-II: Clinical Features and Management01:28

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Esophageal varices often manifest as gastrointestinal bleeding episodes, presenting symptoms like hematemesis (vomiting of blood), hematochezia (passing fresh blood via the rectum), and melena (black, tarry stools). Other signs can include weight loss, anorexia, abdominal discomfort, jaundice, pruritus, altered mental status, and muscle cramps.
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Radiological investigations are paramount in the diagnosis and management of various pulmonary diseases. Two essential investigations are the Pulmonary Angiogram and the Positron Emission Tomography (PET) Scan.
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Related Experiment Video

Updated: Jan 18, 2026

Laparoscopic Radical Antegrade Modular Pancreatosplenectomy via Dorsal-Caudal Artery Approach for Pancreatic Neck-Body Cancer
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Gastrointestinal Bleeding after Particle Radiotherapy for Pancreatic Cancer.

Takeshi Okamoto1, Takafumi Mie2, Tsuyoshi Takeda2

  • 1Department of Hepato-Biliary-Pancreatic Medicine, Cancer Institute Hospital of Japanese Foundation for Cancer Research, Tokyo, Japan, takeshi.okamoto@jfcr.or.jp.

Digestion
|January 16, 2026
PubMed
Summary
This summary is machine-generated.

Gastrointestinal bleeding (GIB) after particle radiotherapy (PRT) for pancreatic cancer (PC) occurred in 32% of patients. While hemostasis was achieved in all cases, concurrent chemotherapy may reduce GIB risk.

Keywords:
Carbon-ion radiotherapyEndoscopyPancreatic ductal adenocarcinomaRadiation therapyRadiation-induced ulcer

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Area of Science:

  • Oncology
  • Radiotherapy
  • Gastroenterology

Background:

  • Particle radiotherapy (PRT) offers a novel treatment for unresectable pancreatic cancer (PC).
  • Real-world data on gastrointestinal bleeding (GIB), a significant adverse event, following PRT for PC is limited.

Purpose of the Study:

  • To evaluate the incidence and outcomes of GIB after PRT for PC.
  • To identify risk factors associated with GIB in this patient cohort.

Main Methods:

  • A single-center retrospective study was conducted.
  • Data from 34 patients undergoing PRT for PC were analyzed.
  • GIB frequency, outcomes, and potential risk factors were assessed.

Main Results:

  • 32% of patients experienced acute GIB post-PRT, with a median onset of 13.2 months.
  • Hemorrhage was managed endoscopically or via embolization in most cases; all achieved hemostasis.
  • Concurrent chemotherapy was linked to a reduced risk of GIB (P=0.05).

Conclusions:

  • Gastrointestinal bleeding following PRT for pancreatic cancer may be more common than previously thought.
  • PRT for advanced pancreatic cancer necessitates careful monitoring for GIB.
  • Concurrent chemotherapy might mitigate GIB risk.