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Updated: Jan 18, 2026

Demonstration of Equal-Intensity Beam Generation by Dielectric Metasurfaces
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Near-Field Topology-Optimized Superchiral Metasurfaces for Enhanced Chiral Sensing.

Zhongjun Jiang1, Soyaib H Sohag1, You Zhou1

  • 1Department of Physics and Optical Science, University of North Carolina at Charlotte, Charlotte, North Carolina 28223, United States.

Nano Letters
|January 16, 2026
PubMed
Summary
This summary is machine-generated.

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Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
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Chirality is the most intriguing yet essential facet of nature, governing life’s biochemical processes and precision. It can be observed from a snail shell pattern in a macroscopic world to an amino acid, the minutest building block of life. Most of the snails around the world have right-coiled shells because of the intrinsic chirality in their genes. All the amino acids present in the human body exist in an enantiomerically pure state, except for glycine - the sole achiral amino acid.
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The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
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Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
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Molecules that possess multiple chiral centers can afford a large number of stereoisomers. For instance, while some molecules like 2-butanol have one chiral center, defined as a tetrahedral carbon atom with four different substituents attached, several molecules like butane-2,3-diol have multiple chiral centers. A simple formula to predict the number of stereoisomers possible for a molecule with n chiral centers is 2n. However, there can be a lower number where some of the stereoisomers are...
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Researchers developed an inverse design framework to optimize nanophotonic platforms for enhanced chiral detection. This method achieves significant chiral enhancement and precise hotspot placement for sensitive enantioselective analysis.

Area of Science:

  • Photonics
  • Chirality
  • Nanotechnology

Background:

  • Chiral detection is crucial for pharmaceuticals and biology.
  • Current nanophotonic chiral sensing has limitations in enhancement and control.

Purpose of the Study:

  • To introduce an inverse design framework for optimizing superchiral near fields in nanostructures.
  • To enable enhanced enantioselective analysis and chiral sensing.

Main Methods:

  • Utilizing an inverse design framework to optimize freeform achiral metasurfaces.
  • Achieving customized chiral hotspot placement within nanostructures.

Main Results:

  • An 820-fold chiral density enhancement was achieved.
  • Ultrasensitive detection of chiral analytes and quantitative readout of enantiomeric excess were demonstrated.
Keywords:
chiral sensingcircular dichroismmetasurfacessuperchiral fieldtopology optimization

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Conclusions:

  • The framework enables precise control over superchiral fields for advanced chiral sensing.
  • This approach is compatible with various spin-based photonic materials for applications in valleytronics and topological photonics.