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Drug Delivery: Miscellaneous Routes01:22

Drug Delivery: Miscellaneous Routes

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Ameliorating Osteoarthritis in Mice Using Silver Nanoparticles
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Drug-loaded nanoparticles for intra-articular injection.

Piaopiao Pan1,2, Konstantina Simou3, Yanting Ouyang4

  • 1School of Pharmaceutical Sciences, Guangzhou University of Chinese Medicine, Guangzhou, PR China.

Plos One
|January 16, 2026
PubMed
Summary
This summary is machine-generated.

Novel drug-loaded nanoparticles (NPs) were developed for intra-articular injection (IAI) to treat early-stage osteoarthritis (OA). These NPs significantly improved joint lubrication and demonstrated sustained drug release and excellent biocompatibility.

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Area of Science:

  • Biomaterials Science
  • Nanotechnology
  • Rheumatology

Background:

  • Osteoarthritis (OA) is a degenerative joint disease requiring effective treatment strategies.
  • Intra-articular injections (IAI) offer localized drug delivery for joint conditions.
  • Current IAI formulations may have limitations in sustained release and lubrication enhancement.

Purpose of the Study:

  • To develop and characterize drug-loaded nanoparticles (NPs) as a model IAI formulation for early-stage OA.
  • To evaluate the lubricating properties of the developed NPs on artificial joint surfaces.
  • To assess the drug release profile and biocompatibility of the NP formulation.

Main Methods:

  • Celecoxib-loaded nanoparticles were prepared using a hybrid homogenization and solvent evaporation technique.
  • Nanoparticle characterization included hydrodynamic diameter and zeta potential measurements.
  • Lubrication was assessed using friction tests, Quartz Crystal Microbalance (QCM), and Atomic Force Microscopy (AFM).
  • Drug release kinetics and chondrocyte cytotoxicity were evaluated.

Main Results:

  • Nanoparticles exhibited hydrodynamic diameters around 200 nm and negative zeta potentials (~ -40 mV).
  • The NPs significantly enhanced lubrication between model joint surfaces (stainless steel and silicone elastomer).
  • Surface adsorption of NPs was identified as the key factor for improved lubrication.
  • Sustained celecoxib release exceeding one week was observed, with excellent biocompatibility in chondrocyte assays.

Conclusions:

  • Drug-loaded nanoparticles show promise as an advanced IAI formulation for osteoarthritis.
  • The NPs provide superior lubrication and sustained drug delivery compared to free celecoxib.
  • The formulation demonstrates good biocompatibility, supporting its potential therapeutic application.