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A Case of Antinuclear Antibody-Negative Dermatomyositis with Interstitial Lung Disease
Background:
Antinuclear antibody (ANA) is important for the diagnosis of autoimmune diseases. When ANA is positive, further specific autoantibody tests are needed to make a definite diagnosis.
Methods:
This article reports a case of a patient with an autoimmune disease who had inconsistent results in the detection of antinuclear antibodies by indirect immunofluorescence assay (IIFA) and linear immunoblotting assay (LIA).
Results:
This patient presented with negative ANA and positive anti-SSA/Ro52.
Conclusions:
IIF-ANA negative and LIA-ANAS positive exists in clinical tests. The combination of IIFA and LIA is important.
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