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Intradialytic kinetics of cardiac biomarkers during high-flux haemodialysis and postdilution haemodiafiltration:

Caroline Liboriussen Drivsholm1,2, Louis Nygaard3,4, Rie Io Glerup3

  • 1Department of Nephrology, Aalborg University Hospital, Aalborg, Denmark c.liboriussen@rn.dk.

BMJ Open
|January 16, 2026
PubMed

Insights

This study examined how hemodialysis (HD) and hemodiafiltration (HDF) affect cardiac biomarkers. Understanding these changes is crucial for diagnosing heart conditions in chronic HD patients.

Area of Science:

  • Nephrology
  • Cardiology
  • Biomarker analysis

Background:

  • Cardiovascular disease (CVD) is the primary cause of death in patients on chronic hemodialysis (HD).
  • Interpretation of cardiac biomarkers like high-sensitivity cardiac troponin (hs-cTn) and N-terminal pro-B-type natriuretic peptide (NT-proBNP) is challenging due to dialysis effects.
  • Limited data exist on the intradialytic kinetics of these biomarkers during HD and hemodiafiltration (HDF).

Purpose of the Study:

  • To investigate the intradialytic kinetics of hs-cTnT, hs-cTnI, and NT-proBNP during HD and HDF.
  • To assess the clearance of these cardiac biomarkers by HD and HDF treatments.
  • To inform the interpretation of cardiac biomarkers in chronic HD patients.

Main Methods:

  • A single-centre, randomized, open-label, crossover study comparing high-flux HD and postdilution HDF.
  • 24 stable patients on chronic HD without acute CVD were included.
  • Blood and dialysate samples were collected at various time points during and after dialysis to determine biomarker concentrations, reduction ratios, and dialyser clearance.

Main Results:

  • The study will investigate changes in concentrations and calculate reduction ratios, dialyser clearance, and clearance by adsorption.
  • Primary outcome is the change from baseline in hs-cTnI, hs-cTnT, and NT-proBNP concentrations during HD and HDF.
  • Dialysate was collected after 120 minutes of dialysis.

Conclusions:

  • Further analysis is needed to determine the specific clearance mechanisms and impact on biomarker levels.
  • Results will be published in a peer-reviewed journal and presented at research meetings.
  • This research aims to improve diagnostic accuracy for cardiovascular conditions in HD patients.
Abstract

Keywords:
Cardiovascular DiseaseClinical ProtocolsDialysisEnd stage renal failureNEPHROLOGYNephrology

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