Related Experiment Video
Updated: Jan 18, 2026
14:48
Visualizing Lung Cellular Adaptations during Combined Ozone and LPS Induced Murine Acute Lung Injury
Published on: March 21, 2021
5.5K
Hypoxia in MASLD: a spatial determinant of the pathogenesis
Isabel Fuster-Martínez1, Vanesa Bernal-Monterde2, Guillaume Bidault1
1Institute of Metabolic Science, University of Cambridge, Cambridge, UK.
Trends in Molecular Medicine
|January 16, 2026
Summary
Metabolic dysfunction-associated steatotic liver disease (MASLD) disrupts liver architecture, causing hypoxia. This review explores how oxygen levels and obstructive sleep apnoea (OSA) impact MASLD progression and liver injury.
Area of Science:
- Hepatology
- Physiology
- Pathology
Background:
- The liver's microarchitecture creates an oxygen gradient essential for zonation.
- Metabolic dysfunction-associated steatotic liver disease (MASLD) impairs this architecture, leading to hypoxia.
- Hypoxia and obstructive sleep apnoea (OSA) are increasingly linked to MASLD.
Purpose of the Study:
- To review intrahepatic oxygen dynamics in MASLD.
- To examine the interplay between OSA and MASLD.
- To elucidate the role of hypoxia in liver injury.
Main Methods:
- Literature review of intrahepatic oxygen gradients.
- Analysis of molecular responses to hypoxia in MASLD.
- Examination of epidemiological and mechanistic links between OSA and MASLD.
Main Results:
- Hypoxia is a key feature of MASLD, driven by architectural disruption.
- Hypoxia-inducible factors are activated in response to low oxygen.
- Chronic intermittent hypoxia from OSA is associated with MASLD progression.
Conclusions:
- Intrahepatic hypoxia is a critical factor in MASLD pathogenesis.
- Oxygen dynamics play a spatial role in determining liver injury severity.
- Understanding hypoxia's role may reveal new therapeutic targets for MASLD.
Related Concept Videos
01:23Hypoxia
2.0K
Hypoxia is a medical condition characterized by an inadequate oxygen supply to body tissues. It typically manifests as a bluish discoloration of the skin and mucosae, especially in fair-skinned individuals, when hemoglobin (Hb) saturation drops below 75%.
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
Types of Hypoxia
There are four primary types of hypoxia, each resulting from a different cause:
1. Anemic hypoxia: This type occurs due to insufficient oxygen delivery caused by a lack of red blood cells (RBCs) or RBCs with abnormal or...
2.0K
01:21Acute Respiratory Failure-II
1.0K
Type I Respiratory Failure, or hypoxemic respiratory failure, occurs when the partial pressure of oxygen (PaO2) in arterial blood falls below 60 mmHg while breathing room air without a corresponding increase in arterial carbon dioxide levels (PaCO2). This condition highlights a significant impairment in the lungs' capacity to oxygenate the blood.
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
The underlying physiological abnormalities that contribute to hypoxemic respiratory failure include:
1.0K
01:30Pulmonary Hypertension: Classification and Pathogenesis
580
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
There are various classifications for PH, each relating to different underlying causes and also...
580
01:20Chronic Obstructive Pulmonary Disease-II: Pathophysiology
4.2K
Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation
Chronic Inflammation
4.2K
01:24Regulation of Angiogenesis and Blood Supply
3.3K
Rapidly dividing tumors, embryos, and wounded tissues require more oxygen than usual, lowering the oxygen concentration in the blood. At low oxygen or hypoxic conditions, an oxygen-sensitive transcription factor called the hypoxia-inducible factor 1 or HIF1 is activated. HIF1 is a dimeric protein of alpha (ɑ) and beta (β) subunits. Under optimal oxygen conditions, HIF1β is present in the nucleus while HIF1ɑ remains in the cytosol. HIF1ɑ is hydroxylated by prolyl...
3.3K
01:29Pneumonia II: Pathophysiology
2.6K
The pathophysiology of pneumonia involves the following steps:
2.6K