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Updated: Jan 18, 2026

Protocol for the Synthesis of Ortho-trifluoromethoxylated Aniline Derivatives
Published on: January 19, 2016
Photoredox-Catalyzed Defluorinative Carbamoylation of α-Trifluoromethylalkenes
Jian-Li Jin1, Yong-Ke He1, Shaoyu Li1,2
1College of Science, Shenyang University of Chemical Technology, Shenyang 110142, China.
Abstract:
β-Fluoroalkylamides constitute privileged molecular frameworks, prominently featured in biologically active compounds, natural products, and pharmaceuticals. Herein, a defluorinative carbamoylation strategy is established for the first time via photocatalytic reductive radical-polar crossover, offering an efficient and versatile route to structurally diverse γ,γ-difluoroallylic amides. This protocol operates under mild, redox-neutral conditions and exhibits broad substrate scope alongside excellent scalability. Furthermore, the gem-difluoroalkene moiety proves amenable to further derivatization, thereby expanding accessible molecular architectures and underscoring the method's utility for the modular assembly of functionally relevant β-fluoroalkylamide frameworks.
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