Related Experiment Video
Updated: Jan 18, 2026
Single-Port Robotic-assisted Transaxillary Breast-conserving Surgery: A Prospective, Single-arm, Non-randomized Phase IIa Clinical Trial
Published on: August 19, 2025
Oncologic Outcomes of Sentinel Lymph Node Biopsy Versus Targeted Axillary Dissection for Node-Positive Breast Cancer
Hussain A Abdulla1, Jennifer McGarry2, Roza Kaczorowska2
1Breast Surgery, St Vincent's University Hospital, Dublin, Ireland. hussainabdulla@svhg.ie.
Background:
Increasing evidence supports the oncologic safety of de-escalating axillary surgery after neoadjuvant chemotherapy (NAC). For patients with node-positive (cN+) breast cancer initially whose axilla is downstaged after NAC (ycN0), sentinel lymph node biopsy (SLNB) or targeted axillary dissection (TAD) is acceptable, with controversy surrounding the optimal technique. This study aimed to assess the oncologic and survival outcomes of SLNB versus TAD for cN+ patients who are converted to ycN0 after NAC.
Methods:
A systematic literature search of relevant databases was conducted. A meta-analysis using the Mantel-Haenszel method was performed to calculate odds ratios (ORs) of axillary recurrence (AR), 3-year disease-free survival (DFS), and overall survival (OS) for SLNB compared with TAD.
Results:
Five studies involving 2849 patients (SLNB, n = 1842; TAD, n = 1007) were included. The rate of AR did not differ between SLNB and TAD (OR, 1.23; 95% confidence interval [CI], 0.33-4.65; p = 0.76). Patients who underwent SLNB had a modestly reduced 3-year DFS (OR, 1.53; 95% CI, 1.11-2.12; p = 0.01) compared with those undergoing TAD. There was no difference in 3-year OS between SLNB and TAD (OR, 2.12; 95% CI, 0.59-7.55; p = 0.25).
Conclusions:
Accurate axillary staging after NAC is important to guide adjuvant therapies. The rate of AR is very low and equivalent after SLNB or TAD for cN+ breast cancer patients who become ycN0 after NAC. Further studies are warranted to confirm whether TAD provides a clear survival advantage compared with SLNB in long-term follow-up evaluation.
