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Microarrays are high-throughput and relatively inexpensive assays that can be automated to analyze large quantities of data at a time. They are used in genome-wide studies to compare gene or protein expression under two varied conditions, such as healthy and diseased states. Microarrays consist of glass or silica slides on which probe molecules are covalently attached through surface functionalization. Most commonly, the slides are prepared through the chemisorption of silanes to silica...
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Neighborhood nonnegative matrix factorization identifies patterns and spatially-variable genes in large-scale spatial

Ragnhild Laursen1,2, Han Chen3, Jack Demaray3

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No abstract available in PubMed .

Keywords:
Gaussian smoothingMERFISHNonnegative matrix factorization (NMF)Spatial hubs

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