[BRCA Pathological Sequence Variants and Systemic and Local Tumor Immune Response in Breast Cancer]
Kana Ogisawa1, Mayuko Hirata, Ayaka Yao
1Dept. of Breast Surgical Oncology, Osaka Metropolitan University Graduate School of Medicine.
Background:
BRCA pathogenic sequence variants(PSVs)are believed to enhance local immune responses through the generation of tumor neoantigens, leading to increased tumor-infiltrating lymphocytes(TILs).
Methods:
In this study, we evaluated the relationship between BRCA-PSVs and both systemic and local tumor immune responses in 93 breast cancer patients who underwent BRCA genetic testing.
Results:
Among them, 16 patients(17.2%)were found to harbor BRCA- PSVs. Although no significant correlations were observed between BRCA-PSVs and absolute lymphocyte count(ALC), TILs, or CD8+ T-cell infiltration, a significant association was noted with the neutrophil-to-lymphocyte ratio(NLR)(p=0.006). Prognostic analysis showed that patients with low-TILs or high-CD8+ T-cell infiltration had significantly better overall survival( p=0.026 and p=0.020, respectively).
Conclusions:
These results suggest that local immune markers, particularly CD8+ T-cells, may serve as important prognostic factors in breast cancers harboring BRCA-PSVs. Further immunophenotypic and spatial profiling is warranted.
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