[A Study on Obstructive Colorectal Cancer Cases Undergoing Primary Tumor Resection Following Chemotherapy after...

We experienced 15 cases of obstructive colorectal cancer treated with chemotherapy after colonic stent placement. Fourteen cases were classified as cStage Ⅲ or Ⅳ, primarily involving distant metastases or extensive local invasion. Chemotherapy, mainly oxaliplatin-based and oral anticancer regimens, was administered for a median of 4 courses before primary tumor resection(median BTS duration:125 days). Although RECIST-defined partial response(PR)was observed in 3 cases, imaging revealed tumor shrinkage in 13 cases, facilitating easier surgical resection. No severe adverse events or stent-related complications were observed during chemotherapy. Compared with cases undergoing surgery without prior chemotherapy (median BTS duration:30 days), operative time, blood loss, and postoperative complication rates were similar, confirming the safety of surgery following stent placement and chemotherapy. Chemotherapy during stent placement and subsequent primary tumor resection was performed safely and may become a viable treatment option.