[A Case of Laparoscopic Low Anterior Resection after Chemotherapy for Sigmoid Colon Cancer with Rectal Invasion]

Surgical resection is the standard treatment for resectable colorectal cancer; however, patients with locally advanced colorectal cancer may face challenges, such as difficulty for the surgeon to achieve R0 resection and a high risk of postoperative recurrence. Although, in the Japanese guidelines, neoadjuvant chemotherapy(NAC)is not recommended for patients with resectable colorectal cancer, clinical studies conducted in Western countries have suggested its clinical benefits. In the FOxTROT trial, NAC was reported to promote tumor regression, contributing to a higher R0 resection rate in patients with locally advanced colorectal cancer. In addition, some reports have indicated that NAC can be performed safely and is not associated with increased postoperative complications. In this case, a patient with sigmoid colon cancer with rectal invasion (cT4b, N1b, M0)received 2 courses of capecitabine-oxaliplatin(CapeOX)therapy as NAC and experienced tumor regression, which enabled the patient to undergo minimally invasive surgery. We report this case because the clinical course suggests the significance of considering the clinical benefits of NAC for locally advanced colorectal cancer, even though NAC is not recommended in Japan.