[A Case of Solid Papillary Carcinoma In Situ-A Case Report]

Area of Science:

• Oncology
• Pathology
• Radiology

Background:

• Solid papillary carcinoma (SPC) is an uncommon breast cancer subtype, representing approximately 1% of all breast cancer cases.
• Early detection and accurate diagnosis are crucial for managing rare breast cancers.
• Hormone receptor status (ER/PgR) and HER2 status are key prognostic indicators.

Purpose of the Study:

• To report a case of solid papillary carcinoma (SPC) in situ in an elderly Japanese woman.
• To highlight the diagnostic and treatment pathway for this rare breast cancer.
• To emphasize the favorable prognosis with timely intervention.

Main Methods:

• Case presentation of an 88-year-old woman with a palpable breast mass and bloody nipple discharge.
• Diagnostic imaging including mammography.
• Core needle biopsy for initial diagnosis.
• Surgical management: total mastectomy and sentinel lymph node biopsy.
• Pathological staging and analysis of hormone receptor and HER2 status.

Main Results:

• Mammography showed a well-defined, high-concentration mass.
• Biopsy was suspicious for SPC, with positive estrogen receptor (ER) and progesterone receptor (PgR) status, and negative HER2.
• Pathological diagnosis confirmed stage 0 (Tis, N0M0) SPC in situ with neuroendocrine markers.
• The patient experienced no recurrence over a 4-year follow-up period.

Conclusions:

• Solid papillary carcinoma in situ can present with subtle symptoms like bloody nipple discharge.
• Early detection and surgical resection, even for rare types like SPC, lead to excellent outcomes.
• This case underscores the importance of thorough pathological evaluation for accurate breast cancer subtyping and management.