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[Bone Only Metastasis Breast Cancer with Effective Disease Control by Primary Tumor Resection-A Case Report]
Keita Adachi1, Junko Nagae, Hitomi Kubota
1Dept. of Breast and Endocrine Surgery, Nippon Dental University Hospital.
Gan to Kagaku Ryoho. Cancer & Chemotherapy
|January 17, 2026
Summary
Locoregional surgery effectively treated metastatic breast cancer in the bones for a 52-year-old woman. This approach, combined with systemic therapies, achieved stable disease and no recurrence two years post-surgery.
Area of Science:
- Oncology
- Surgical Oncology
- Breast Cancer Research
Background:
- Metastatic breast cancer (MBC) presents significant treatment challenges.
- Bone metastases are a common and debilitating complication of breast cancer.
- Effective local and systemic management strategies are crucial for MBC patients.
Purpose of the Study:
- To report a case of metastatic breast cancer with bone involvement.
- To evaluate the efficacy of locoregional surgery in managing bone metastases from breast cancer.
- To assess the long-term outcomes following surgical and systemic treatment.
Main Methods:
- A 52-year-old female patient diagnosed with bilateral invasive ductal carcinoma.
- Initial presentation included a palpable breast mass and skin redness.
- Diagnostic workup revealed bilateral breast masses and multiple bone metastases (thoracic and lumbar spine).
- Treatment involved bilateral mastectomy for local control, followed by chemotherapy and endocrine therapy.
Main Results:
- Histopathology confirmed invasive ductal carcinoma (scirrhous type), hormone receptor positive, HER2 negative.
- Post-surgery, chemotherapy and endocrine therapy led to decreased tumor markers.
- Bone metastases remained stable disease (SD) without progression.
- No local recurrence or new lesions observed at 2 years and 2 months post-surgery.
Conclusions:
- Locoregional surgery can be an effective component in the management of metastatic breast cancer with bone involvement.
- A multimodal approach combining surgery, chemotherapy, and endocrine therapy can achieve durable disease control.
- This case highlights the potential for successful long-term outcomes in select MBC patients with bone metastases.
