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Updated: Jan 18, 2026

Modeling Primary Bone Tumors and Bone Metastasis with Solid Tumor Graft Implantation into Bone
Published on: September 9, 2020
[Bone Only Metastasis Breast Cancer with Effective Disease Control by Primary Tumor Resection-A Case Report]
Keita Adachi1, Junko Nagae, Hitomi Kubota
1Dept. of Breast and Endocrine Surgery, Nippon Dental University Hospital.
Abstract:
We report a case of metastatic breast cancer in the bones effectively treated with locoregional surgery. The patient was a 52-year-old woman who presented with an increasing right breast lump. A mass accompanied by skin redness 5 cm in diameter was palpable in the AC area of the right breast. Ultrasonography revealed multiple other masses in the bilateral breasts that were suspected to be malignant. Core needle biopsy led to the diagnosis of invasive ductal carcinoma in both breasts. Tumor marker 1-CTP was elevated, and bone scintigraphy showed multiple abnormal accumulations in the thoracic and lumbar spine, indicating multiple bone metastases. Bilateral mastectomy was first performed for local control. Histopathological diagnosis was invasive ductal carcinoma(scirrhous type)in both breasts, with multiple lesions, hormone receptor positive, and HER2 negative. After surgery, chemotherapy followed by endocrine therapy was administered, and tumor markers decreased, and bone metastases remained stable disease(SD). Two years and 2 months after surgery, no local recurrence or appearance of new lesions have been observed.

