Alpha-Lipoic Acid Restored Antioxidant Capacity of Megalobrama amblycephala Inhibited by Ammonia
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View abstract on PubMed
Summary
This summary is machine-generated.Dietary alpha-lipoic acid (α-LA) supplementation aids blunt snout bream recovery from ammonia stress. Supplemented fish showed restored antioxidant capacity and reduced oxidative damage, highlighting α-LA
Area Of Science
- Aquatic toxicology
- Fish physiology
- Nutritional biochemistry
Background
- Ammonia is a common aquaculture stressor impacting fish health and antioxidant systems.
- Oxidative stress, indicated by reduced antioxidant enzymes and increased lipid peroxidation, is a key consequence of ammonia exposure.
- Alpha-lipoic acid (α-LA) is a potent antioxidant with potential to mitigate stress-induced damage.
Purpose Of The Study
- To evaluate the efficacy of dietary alpha-lipoic acid (α-LA) in restoring antioxidant capacity of blunt snout bream (Megalobrama amblycephala) juveniles post-ammonia stress.
- To investigate the impact of varying α-LA dietary levels on key antioxidant enzyme activities and oxidative stress markers in fish gills and liver.
Main Methods
- Blunt snout bream juveniles were exposed to three ammonia concentrations (0, 5.45, 10.89 mg/L) for 72 hours.
- Following stress, fish were fed diets supplemented with 0, 0.6, or 1.2 g/kg α-LA for 72 hours during a recovery period.
- Antioxidant enzyme activities (T-AOC, SOD, CAT, GPX) and malondialdehyde (MDA) content were measured in gill and liver tissues.
Main Results
- Ammonia stress significantly reduced antioxidant enzyme activities and increased MDA levels, indicating oxidative damage.
- Dietary α-LA supplementation significantly enhanced T-AOC, SOD, and CAT activities in gills and liver compared to unsupplemented controls post-stress.
- MDA content was significantly reduced in α-LA supplemented groups, and enzyme activities showed a positive correlation with dietary α-LA levels.
Conclusions
- Dietary alpha-lipoic acid effectively restores antioxidant capacity in blunt snout bream juveniles following ammonia-induced stress.
- α-LA supplementation mitigates oxidative stress by enhancing antioxidant enzyme function and reducing lipid peroxidation.
- The findings support the use of dietary α-LA as a nutritional strategy to improve fish resilience against ammonia toxicity in aquaculture.
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