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Related Experiment Video

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Deep Brain Stimulation for Disorders of Consciousness: An Individual Patient Data Meta-Analysis.

Marcus Jun Rui Lee1, Pranav Shivaprakash Rao1, Wei Wei2

  • 1Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Neuromodulation : Journal of the International Neuromodulation Society
|January 17, 2026
PubMed
Summary

Deep brain stimulation (DBS) offers modest improvements in conscious awareness for some patients with disorders of consciousness (DoC). However, benefits are limited, risks are substantial, and patient selection is crucial for future trials.

Keywords:
Arousalcentro-median parafascicular complexdeep brain stimulation (DBS)disorders of consciousness (DoC)neuromodulation

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Area of Science:

  • Neuroscience
  • Neurosurgery
  • Neurology

Background:

  • Deep brain stimulation (DBS) is explored as a therapeutic option for disorders of consciousness (DoC).
  • DBS aims to modulate brain activity and promote arousal through electrical impulses in deep brain nuclei.

Purpose of the Study:

  • To assess the therapeutic effect of DBS on improving conscious awareness in patients with DoC.
  • To identify predictors of treatment response to DBS in DoC patients.

Main Methods:

  • Individual patient data meta-analysis of 9 studies involving 81 patients with DoC.
  • Primary outcome: Coma Recovery Scale-Revised (CRS-R).
  • Subgroup analyses by age, DoC duration, etiology, and DBS target; pooled using random-effects models.

Main Results:

  • Pooled mean CRS-R improvement was 2.15, indicating a modest effect.
  • 39.5% achieved clinically important difference (≥3 CRS-R points); 30.9% transitioned to a higher DoC category.
  • Younger patients and shorter DoC duration correlated with better outcomes; hypoxic-ischemic encephalopathy showed marginal response.

Conclusions:

  • DBS may offer limited benefits for conscious awareness in selected DoC patients, with significant risks.
  • Rigorous patient selection and standardized protocols are essential for clinical decision-making and future research.