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Updated: Jul 15, 2026
An Isolated Semi-intact Preparation of the Mouse Vestibular Sensory Epithelium for Electrophysiology and High-resolution Two-photon Microscopy
Published on: June 13, 2013
Dynamics of Morphological Changes of Axons in the Lateral (Deiters) Vestibular Nuclei in Mice after Long-Term
I B Mikheeva1, N S Zhuikova2, L L Pavlik2
1Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, Pushchino, Russia. mikheirina@yandex.ru.
Abstract:
Mice were subjected to vestibular stimulation (rotation at 80 rpm for 8 h) and behavioral disturbances and morphological changes in the Deiters' vestibular nuclei were studied 1 h and 2, 5, and 7 days after stimulation. Horizontal and vertical motor activity decreased after long-term vestibular stimulation and recovered after 1 day. Short- and long-term disturbances in the morphology of Deiters' neurons and neuropil were detected. Disturbances in the structure of neurons were no longer detected 2 days after stimulation, while disturbances in myelinated axons in the neuropil persisted for up to 7 days. These disturbances manifested by abnormal water distribution and pronounced damage to the myelin sheath. It is assumed that long-term edema of myelinated axons is a target for therapeutic intervention in diseases associated with axonal demyelination.
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